ReviewJournal of neurology2018
Patent foramen ovale and stroke.
Review in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 104 citations in OpenAlex.
- Right-to-left shunt is associated with reduced cerebral vascular reactivity in migraine patients with aura.Frontiers in neurology · 2026Observational
- Patent foramen ovale is associated with white matter hyperintensities in young adults: a case-control study.Frontiers in neurology · 2026Article
- Electrocardiographic Predictors of High-Risk Patent Foramen Ovale Anatomy Defined by Transesophageal Echocardiography.Journal of clinical medicine · 2025Article
- Occurrence of cerebral COJournal of medical case reports · 2025Review
- Acute Hemichorea in a Young Patient Secondary to Ischemic Infarction in the Right Lentiform Nucleus: A Case Report.Cureus · 2025Article
- A patient with patent foramen ovale associated ischemic stroke combined with hemorrhagic transformation: A case report.Medicine · 2025Article
- Hotspots and frontiers in patent foramen ovale research: a bibliometric and visualization analysis from 2003 to 2023.Frontiers in cardiovascular medicine · 2025Article
- Atrial fibrillation in young stroke patients: Associated factors and outcomes in a nationwide analysis.European journal of neurology · 2025Article
- Clinical characteristics and risk factors for perinatal arterial ischemic and hemorrhagic stroke: a comparative study.Frontiers in pediatrics · 2025Article
- Cervical cancer with patent foramen ovale metastasis to the left ventricle: a case report.World journal of surgical oncology · 2024Article
- Evaluation of Triglyceride Glucose Index in Patients with Patent Foramen Ovale Who Experienced Cryptogenic Stroke.Journal of clinical medicine · 2024Article
- An Automated Heart Shunt Recognition Pipeline Using Deep Neural Networks.Journal of imaging informatics in medicine · 2024Article
- The Modified Risk of Paradoxical Embolism Score Is Associated with Patent Foramen Ovale in Patients with Ischemic Stroke: A Nationwide US Analysis.Journal of cardiovascular development and disease · 2024Article
- Review
- Review
- Unresponsiveness to Chiari Malformation Type I Surgery Can Be Related to the Accompanying Chiari Network.Cureus · 2024Article
- Isolated Ischemic Inferior Rectus Paresis Related to Patent Foramen Ovale.Neuro-ophthalmology (Aeolus Press) · 2024Article
- The predictive value of abnormal electrocardiogram for patent foramen ovale: A retrospective study.Clinical cardiology · 2023Article
- Contrast-enhanced transcranial doppler versus contrast transthoracic echocardiography for right-to-left shunt diagnosis.Journal of clinical monitoring and computing · 2023Article
- Cryptogenic Stroke Caused by a Newly Diagnosed Patent Foramen Ovale in a Healthy Young Adult.Cureus · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A patent foramen ovale (PFO) is a highly prevalent finding in cryptogenic ischaemic stroke, particularly in young adults. A common challenge in clinical practice is to distinguish between incidental and pathogenic PFO. Some clinical features and tools such as the Risk of Paradoxical Embolism score may help determining the probability of a stroke-related PFO. Nonetheless, the best therapeutic option to reduce stroke recurrence after a cryptogenic stroke with PFO has been a matter of debate for a long time. We review the mechanisms of stroke-related PFO, together with its clinical features and diagnostic criteria. In addition, we focus on the methodological details and results from new studies in the field of secondary prevention. In contrast to prior evidence, the data from three recent clinical trials and an updated meta-analysis favour PFO closure over medical treatment after cryptogenic stroke/TIA for the prevention of stroke recurrence. The PFO closure device procedure is not associated with higher mortality or cardiovascular events, except for a small increase in the occurrence of transient atrial fibrillation. Furthermore, the benefit of PFO closure was higher among those with atrial septal aneurysm and PFO with large right-to-left shunt. Future studies should address pending issues such as the option for anticoagulants or antiplatelet in patients not undergoing closure, the duration of antiplatelet treatment after PFO closure and the role of PFO closure in patients older than 60.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.