ArticleMedical science monitor : international medical journal of experimental and clinical research2018
Preservation of Hearing Following Cochlear Implantation Using Different Steroid Therapy Regimens: A Prospective Clinical Study.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Hearing Preservation Rates After Cochlear Implantation Using Soft Surgery Techniques.The Laryngoscope · 2026Article
- Electrode impedance in cochlear implantation: determinants, dynamics, and clinical implications.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Review
- Effects of Preoperative Postauricular Glucocorticoid Injection on Electrode Impedance in Cochlear Implantation.Healthcare (Basel, Switzerland) · 2026Article
- Towards a consensus on hearing and structure preservation in cochlear implantation surgery: results of the HEARRING international group survey.Frontiers in surgery · 2026Article
- Hearing Preservation After Cochlear Implantation with the Advanced Bionics HiFocus™ SlimJ Electrode Array.The journal of international advanced otology · 2025Article
- Mesenchymal stem cell- derived exosomes as cell-free therapeutics for sensorineural hearing loss.Biomolecules & biomedicine · 2025Review
- Sialyllactose preserves residual hearing after cochlear implantation.Scientific reports · 2024Article
- Immunohistochemical localization of glucocorticoid receptors in the human cochlea.Brain research · 2023Article
- Cochlear implantation impairs intracochlear microcirculation and counteracts iNOS induction in guinea pigs.Frontiers in cellular neuroscience · 2023Article
- The Clinical Effect of Steroids for Hearing Preservation in Cochlear Implantation: Conclusions Based on Three Cochlear Implant Systems and Two Administration Regimes.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Minimally Traumatic Cochlear Implant Surgery: Expert Opinion in 2010 and 2020.Journal of personalized medicine · 2022Article
- The Effect of Pluronic-Coated Gold Nanoparticles in Hearing Preservation Following Cochlear Implantation-Pilot Study.Audiology research · 2022Article
- The Clinical Effect of Steroid Therapy on Preserving Residual Hearing after Cochlear Implantation with the Advanced Bionics HiRes Ultra 3D Cochlear Implant System.Life (Basel, Switzerland) · 2022Article
- Tetrandrine Prevents Neomycin-Induced Ototoxicity by Promoting Steroid Biosynthesis.Frontiers in bioengineering and biotechnology · 2022Article
- Sense of taste in patients after cochlear implantation-preliminary study.African health sciences · 2021Article
- Health-related quality of life in adults with profound postlingual hearing loss before and after cochlear implantation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- The Clinical Effects of Steroids Therapy in the Preserving Residual Hearing after Cochlear Implantation with the OTICON Neuro Zti EVO.Journal of clinical medicine · 2021Article
- First-in-human intracochlear application of human stromal cell-derived extracellular vesicles.Journal of extracellular vesicles · 2021Article
- Differential Effects of Low- and High-Dose Dexamethasone on Electrically Induced Damage of the Cultured Organ of Corti.Neurotoxicity research · 2020Article
- Dose-Dependent Transient Decrease of Impedances by Deep Intracochlear Injection of Triamcinolone With a Cochlear Catheter Prior to Cochlear Implantation-1 Year Data.Frontiers in neurology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND A prospective clinical study was conducted to assess different regimens of steroid therapy and preservation of hearing following cochlear implantation. MATERIAL AND METHODS Study participants were ≥18 years-of-age, with a cochlear duct length ≥27.1 mm measured by computed tomography (CT), with hearing sound levels in the range of 10-120 decibels (dB) and sound frequencies of 125-250 hertz (Hz); sound levels of 35-120 dB and frequencies of 500-1,000 Hz; sound levels of 75-120 dB and frequencies of 2,000-8,000 Hz. Study exclusion criteria included diseases with contraindications for steroid therapy or medications that increased the effects of steroids. Patients had cochlear implantation and were divided into three treatment groups: intravenous (IV) steroid therapy (standard steroid therapy): combined oral and IV steroid therapy (prolonged steroid therapy); and a control group (cochlear implantation without steroid therapy). Hearing preservation was established by pure tone audiometry based on the pre-operative and postoperative average hearing thresholds according to the formula developed by the HEARRING Network. RESULTS There were 36 patients included in the study. In all cases, the cochlear implant electrode was inserted via the round window approach with a straight electrode length of 28 mm. Patients with combined oral and IV steroid therapy (prolonged steroid therapy) had better results when compared with patients with intravenous (IV) steroid therapy (standard steroid therapy) and the control group. CONCLUSIONS Prolonged steroid therapy using combined oral and IV steroids stabilized hearing thresholds and preserved hearing in adult patients following cochlear implantation.
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