Evidence map›Paper›PMID 29680855›Full record

ArticleMedicina oral, patologia oral y cirugia bucal2018

miR-1226 detection in GCF as potential biomarker of chronic periodontitis: A pilot study.

P Micó-Martínez, J-L García-Giménez, M Seco-Cervera, A López-Roldán, P-J Almiñana-Pastor, F Alpiste-Illueca, F-V Pallardó

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicina oral, patologia oral y cirugia bucal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 6 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Epigenetics and periodontics: A systematic review.Medicina oral, patologia oral y cirugia bucal · 2019
    Pooled it
  7. Review
  8. Review
  9. Emerging roles of exosomes in oral diseases progression.International journal of oral science · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Study on the Mechanism of miR-146a in Gingival Mesenchymal Stem Cells.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Detection of Salivary miRNAs That Predict Chronic Periodontitis Progression: A Cohort Study.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

P Micó-MartínezDept. of Stomatology, Faculty of Medicine and Dentistry, University of Valencia, C/Gascó Oliag, 1, 46010 Valencia, Spain, paumico90@gmail.com.
J-L García-Giménez
M Seco-Cervera
A López-Roldán
P-J Almiñana-Pastor
F Alpiste-Illueca
F-V Pallardó
Universitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe study and identification of new biomarkers for periodontal disease, such as microRNAs (miRNAs), may give us more information about the location and severity of the disease and will serve as a basis for treatment planning and disease-monitoring. miRNAs are a group of small RNAs which are involved in gene regulation by binding to their messenger RNA target (mRNA). In this pilot study, the procedure for purifying miRNAs from gingival crevicular fluid (GCF) was, for the first time, described. In addition, the concentration of miRNAs in GCF was analyzed and compared between patients with moderate or severe chronic periodontitis (CP) and healthy controls. MATERIAL AND

methodsGCF samples were collected from single-rooted teeth of patients with moderate or severe CP (n=9) and of healthy individuals (n=9). miRNAs were isolated from GCF using miRNeasy Serum/Plasma kit (Qiagen, CA. USA). Reverse transcription polymerase chain reaction (qRT-PCR) was used to determine the expression of a series of miRNAs candidates that are related to bone metabolism. The significance of differences in miRNA levels between both groups was determined using Mann-Whitney U test.

resultsThe results from this pilot study indicate that miRNAs can be isolated from GCF. Six different miRNAs were analyzed (miR-671, miR-122, miR-1306, miR-27a, miR-223, miR-1226), but only miR-1226 showed statically significant differences between the CP group and healthy controls (p<0.05). This miRNA was downregulated in patients with CP.

conclusionsWithin the limitations of the present study, it may be concluded that miR-1226 can be a promising biomarker for periodontal disease, adding relevant information to common clinical parameters used for diagnosis and prognosis of periodontitis.

Indexed as

AdultBiomarkersChronic PeriodontitisFemaleGingival Crevicular FluidHumansMaleMicroRNAsMiddle AgedPilot ProjectsBiomarkersMicroRNAsMIRN1226 microRNA, human

Identifiers

PMID29680855
PMCPMC5945245
OpenAlexW2799861438

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.