Trial reportDevelopmental cognitive neuroscience2018
Neurophysiological differences in the adolescent brain following a single night of restricted sleep - A 7T fMRI study.
Trial report in Developmental cognitive neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Trial
- Structural Alterations in Large-scale Brain Networks and Their Relationship with Sleep Disturbances in the Adolescent Population.Scientific reports · 2020Trial
- Objective sleep efficiency links to cortisol stress recovery via dorsolateral prefrontal-hippocampal regulation.Psychological medicine · 2026Article
- Shorter weeknight sleep duration mediates the relationship between earlier adrenarche and depressed mood in adolescents.Journal of affective disorders · 2025Article
- Alterations of sleep deprivation on brain function: A coordinate-based resting-state functional magnetic resonance imaging meta-analysis.World journal of psychiatry · 2024Article
- Reduced Resting-State EEG Power Spectra and Functional Connectivity after 24 and 36 Hours of Sleep Deprivation.Brain sciences · 2023Article
- Article
- Socioeconomic disparities in sleep duration are associated with cortical thickness in children.Brain and behavior · 2023Article
- Association between sleep habits and behavioral problems in early adolescence: a descriptive study.BMC psychology · 2022Article
- Adolescent sleep and the foundations of prefrontal cortical development and dysfunction.Progress in neurobiology · 2022Review
- Sleep to Internalizing Pathway in Young Adolescents (SIPYA): A proposed neurodevelopmental model.Neuroscience and biobehavioral reviews · 2022Review
- Adolescent Technology-use Rules and Sleep in a Large Representative Sample.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2022Article
- Altered Regional Homogeneity in Patients With Diabetic Erectile Dysfunction: A Resting-State fMRI Study.Frontiers in endocrinology · 2022Article
- Decreased resting-state alpha-band activation and functional connectivity after sleep deprivation.Scientific reports · 2021Article
- Irregular sleep habits, regional grey matter volumes, and psychological functioning in adolescents.PloS one · 2021Article
- Neurodevelopmental Consequences of Pediatric Cancer and Its Treatment: The Role of Sleep.Brain sciences · 2020Review
- Differential functional patterns of the human posterior cingulate cortex during activation and deactivation: a meta-analytic connectivity model.Experimental brain research · 2019Article
- Implications of the ABCD study for developmental neuroscience.Developmental cognitive neuroscience · 2018Article
Corrections and comments
- Erratum issuedErratum.2020
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep deprivation in youth has garnered international attention in recent years, as correlational studies have demonstrated significant relationships between lack of sleep and detrimental behavioral and academic outcomes. However, no study to date has systematically examined the neurophysiological consequences of a single night of sleep restriction (i.e., 4 h) in adolescents using ultra-high field functional neuroimaging. Much of what we know regarding the neural consequences of sleep deprivation has come from the adult literature, and among those studies, the majority use region of interest (ROI) approaches, thus disregarding the dynamic mechanisms that may subserve the behavioral effects of sleep restriction. Leveraging a crossover within-subjects design, we demonstrate that pivotal brain regions involved in the default mode and limbic regulatory centers have disrupted functioning following a night of restricted sleep compared to a night of "normal sleep". Specifically, a normal night (i.e., 8 h) of sleep led to increased global and local efficiency of bilateral amygdala, and less efficiency in the posterior cingulate, as measured by graph theory, compared to a night of sleep restriction. Furthermore, aberrant functional connectivity patterns were identified in key fronto-limbic circuitry, suggesting a potential pathophysiological mechanism underlying the widespread effects of sleep deprivation in youth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.