Evidence map›Paper›PMID 29680476›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2018

Longitudinal Effects of Alcohol Consumption on the Hippocampus and Parahippocampus in College Students.

Shashwath A Meda, Keith A Hawkins, Alecia D Dager, Howard Tennen, Sabin Khadka, Carol S Austad, Rebecca M Wood, Sarah Raskin, Carolyn R Fallahi, Godfrey D Pearlson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Shashwath A MedaOlin Neuropsychiatry Research Center, Hartford HealthCare Corporation, Hartford, Connecticut. Electronic address: shashwath.meda@hhchealth.org.
Keith A HawkinsDepartment of Psychiatry, Yale University, New Haven, Connecticut.
Alecia D DagerOlin Neuropsychiatry Research Center, Hartford HealthCare Corporation, Hartford, Connecticut; Department of Psychiatry, Yale University, New Haven, Connecticut.
Howard TennenDepartment of Community Medicine, University of Connecticut School of Medicine, Farmington, Connecticut.
Sabin KhadkaOlin Neuropsychiatry Research Center, Hartford HealthCare Corporation, Hartford, Connecticut.
Carol S AustadDepartment of Psychology, Central Connecticut State University, New Britain, Connecticut.
Rebecca M WoodDepartment of Psychology, Central Connecticut State University, New Britain, Connecticut.
Sarah RaskinDepartment of Psychology and Neurosciences, Trinity College, Hartford, Connecticut.
Carolyn R FallahiDepartment of Psychology, Central Connecticut State University, New Britain, Connecticut.
Godfrey D PearlsonOlin Neuropsychiatry Research Center, Hartford HealthCare Corporation, Hartford, Connecticut; Department of Psychiatry, Yale University, New Haven, Connecticut; Department of Neuroscience, Yale University, New Haven, Connecticut.
Central Connecticut State University · USHartford Financial Services (United States)Hartford Hospital · USYale University · USUniversity of Connecticut · US

Funding

Alcohol Use in College Students:Cognition and fMRIR01AA016599 · NIAAA · YALE UNIVERSITY · PI PEARLSON, GODFREY D · 2008 to 2012
$3.0M
Genetic architecture of alcohol misuse candidate endophenotypesRC1AA019036 · NIAAA · YALE UNIVERSITY · PI PEARLSON, GODFREY D · 2009 to 2010
$997k
NIAAA NIH HHS R01 AA016599NIAAA NIH HHS RC1 AA019036
6 · The paper itself

Abstract

backgroundThe hazardous effects of alcohol consumption on both the hippocampus and memory have been well established. However, the longitudinal effects of ethanol on the developing brain and related consequences on memory are not well explored. Given the above, we investigated the longitudinal effects of college drinking on hippocampal volume in emerging college adults.

methodsData were derived from the longitudinal Brain and Alcohol Research with College Students study. A subset of 146 freshmen (mean age at baseline = 18.5 years) underwent brain magnetic resonance imaging scans at baseline and 24 months later. Four drinking-related measures derived from monthly surveys were reduced to a single alcohol use index using principal component analysis. Gray matter volumetric change (GMV-c) data were derived using a longitudinal pipeline. Voxelwise hippocampal/para-hippocampal GMV-c associations with the drinking index were derived using a multiple regression framework within SPM12. Supplementary associations were assessed between GMV-c and memory scores computed from the California Verbal Learning Test-II (assessed at the end of the study), and between GMV-c and total alcohol-induced memory blackouts.

resultsLarger alcohol use index was associated with an accelerated GMV decline in the hippocampus/para-hippocampus. Also, larger hippocampal volume decline was associated with poorer memory performance and more memory blackouts.

conclusionsOur study extends prior cross-sectional literature by showing that a heavier drinking burden while in college is associated with greater hippocampal GMV decline that is in turn associated with poorer memory scores, all of which could ultimately have a significant impact on student success.

Indexed as

Alcohol Drinking in CollegeAdolescentAdultAlcoholismCross-Sectional StudiesHippocampusHumansLongitudinal StudiesMagnetic Resonance ImagingMental RecallParahippocampal GyrusVerbal LearningYoung AdultBingeCollegeCorticalHippocampusMorphometrySubstance use

Identifiers

PMID29680476
PMCPMC6062479
OpenAlexW2790405257

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.