ArticleThe spine journal : official journal of the North American Spine Society2018
A longitudinal study of disc height narrowing and facet joint osteoarthritis at the thoracic and lumbar spine, evaluated by computed tomography: the Framingham Study.
Article in The spine journal : official journal of the North American Spine Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Mesenchymal stem cells can improve discogenic pain in patients with intervertebral disc degeneration: a systematic review and meta-analysis.Frontiers in bioengineering and biotechnology · 2023Pooled it
- Bone-Targeted Therapies and Spinal Morphometry in Postmenopausal Osteoporosis: A Real-World Longitudinal Retrospective Study.Bioengineering (Basel, Switzerland) · 2026Article
- ISSLS Prize in Clinical Science 2026: Data-driven classification of lumbar spine degeneration trajectories in chronic low back pain.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Risk Factor Analysis of Residual Low Back Pain After Unilateral Biportal Endoscopic Discectomy in Patients With Lumbar Disc Herniation.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Quantitative computed tomography provides improved accuracy for diagnosis of lumbar osteoporosis in patients with facet joint osteoarthritis: a cross-sectional study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Improving Golf Swing Kinematics in a 78-Year-Old Golfer with Lower Back Pain: A Case Report.The American journal of case reports · 2024Article
- Association of vertebral fractures with worsening degenerative changes of the spine: a longitudinal study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- DNM3OS/miR-127-5p/CDH11, activates Wnt3a/β-catenin/LEF-1 pathway to form a positive feedback and aggravate spine facet joint osteoarthritis.Non-coding RNA research · 2024Article
- Platelet-Rich Plasma for Degenerative Spine Disease: A Brief Overview.Spine surgery and related research · 2024Review
- Analyzing isolated degeneration of lumbar facet joints: implications for degenerative instability and lumbar biomechanics using finite element analysis.Frontiers in bioengineering and biotechnology · 2024Article
- Sex Difference in OA: Should We Blame Estrogen?European journal of rheumatology · 2023Article
- Vertebral Bone Mineral Density, Vertebral Strength, and Syndesmophyte Growth in Ankylosing Spondylitis: The Importance of Bridging.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- In vivo fluid transport in human intervertebral discs varies by spinal level and disc region.JOR spine · 2022Article
- Intervertebral disc degeneration is rescued by TGFβ/BMP signaling modulation in an ex vivo filamin B mouse model.Bone research · 2022Article
- Low-dose mesenchymal stem cell therapy for discogenic pain: safety and efficacy results from a 1-year feasibility study.Future science OA · 2022Article
- Chinese Association for the Study of Pain: Experts consensus on ultrasound-guided injections for the treatment of spinal pain in China (2020 edition).World journal of clinical cases · 2021Review
- Improving the Management of Patients with Osteoporosis Undergoing Spinal Fusion: The Need for a Bone Mineral Density-Matched Interbody Cage.Orthopedic research and reviews · 2021Article
- How do high preoperative pain scores impact the clinical course and outcomes for patients undergoing lumbar microdiscectomy?Journal of neurosurgery. Spine · 2020Article
- Adult spinal deformity and its relationship with height loss: a 34-year longitudinal cohort study.BMC musculoskeletal disorders · 2020Article
- Association between lumbar disc herniation and facet joint osteoarthritis.BMC musculoskeletal disorders · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
background contextPrevalence and progression of disc height narrowing (DHN) and facet joint osteoarthritis (FJOA) in the thoracic and lumbar regions in non-clinical populations are not well established. PURPOSE: The present study aimed to use computed tomography (CT) images to determine the prevalence and progression of DHN and FJOA according to age, sex, and spinal region. STUDY
designThis is a 6-year longitudinal study. SAMPLE: A total of 1,195 members of the Framingham Study (mean baseline age 61±9 years) were included in the study. OUTCOME MEASURES: We compared the prevalence and progression (new or worsening) of moderate-to-severe DHN and FJOA by age, sex, and spinal region.
methodsA musculoskeletal radiologist evaluated DHN and FJOA from T4/T5 to L4/L5 on baseline and follow-up CT images using a semi-quantitative scale: 0=normal, 1=mild, 2=moderate, and 3=severe.
resultsOne-third or more of women and men ages 40-59 years at baseline had imaged-based evidence of prevalent DHN, more than half had prevalent FJOA, and DHN and FJOA prevalence increased approximately two- to fourfold in those age 60-69 and 70-89 years at baseline, respectively (p<.01). Progression of DHN and FJOA occurred more frequently at the lumbar than at the thoracic spine and more in women than in men (DHN: odds ratio [OR]=1.42, 95% confidence interval [CI]=1.07, 1.88; FJOA: OR=1.70, CI=1.33, 2.17).
conclusionsPrevalence and progression of moderate-to-severe DHN and FJOA are common in non-clinical populations of older adults. The high frequency of spinal degeneration observed on CTs in this community-based study may contribute to challenges in interpreting the clinical significance of imaging evidence of DHN and FJOA. Future studies investigating the association of CT-based spinal degenerative features with pain and functional impairments in population-based samples are needed to help determine the clinical significance of imaged-based findings of DHN and FJOA.
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