ArticleThe Journal of allergy and clinical immunology2019
Eleven loci with new reproducible genetic associations with allergic disease risk.
Article in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 5 syntheses or guidelines pooled it, 64 citations in OpenAlex.
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- Trans-ethnic genome-wide association study of severe COVID-19.Communications biology · 2021Pooled it
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- Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.Genome medicine · 2020Pooled it
- Dynamic CD4+ T Cell Genetics Identifies Candidate Therapeutic Targets for Allergic Rhinitis: Mendelian Randomization with Exploratory Single-Cell Contextualization.Biomedicines · 2026Article
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- Chromatin accessibility profiling of Treg cells in acute urticaria.Epigenetics · 2025Article
- Genome-Wide Blood DNA Methylation Profiling in Birch Pollen Allergic Patients Undergoing Allergen-Specific Immunotherapy.Allergy · 2025Article
- Association of ZNF608 Polymorphisms With House Dust Mite-Induced Allergic Rhinitis.Clinical and translational allergy · 2025Article
- Update on the genetics of allergic diseases.The Journal of allergy and clinical immunology · 2025Review
- Machine learning analysis of FOSL2 and RHoBTB1 as central immunological regulators in knee osteoarthritis synovium.The Journal of international medical research · 2025Article
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- Identification of the regulatory circuit governing corneal epithelial fate determination and disease.PLoS biology · 2023Article
- Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers.Journal of clinical medicine · 2023Review
- A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection.Mucosal immunology · 2023Article
- Genome-wide admixture and association analysis identifies African ancestry-specific risk loci of eosinophilic esophagitis in African Americans.The Journal of allergy and clinical immunology · 2023Article
- Epicutaneous Sensitization and Food Allergy: Preventive Strategies Targeting Skin Barrier Repair-Facts and Challenges.Nutrients · 2023Review
- B cell- and T cell-intrinsic regulation of germinal centers by thymic stromal lymphopoietin signaling.Science immunology · 2023Article
- A small proline-rich protein (SPRR) gene variant contributes to atopic eczema and eczema-associated asthma susceptibility.Postepy dermatologii i alergologii · 2022Article
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24 authors at 11 institutions in 6 countries.
Funding
Abstract
backgroundA recent genome-wide association study (GWAS) identified 99 loci that contain genetic risk variants shared between asthma, hay fever, and eczema. Many more risk loci shared between these common allergic diseases remain to be discovered, which could point to new therapeutic opportunities.
objectiveWe sought to identify novel risk loci shared between asthma, hay fever, and eczema by applying a gene-based test of association to results from a published GWAS that included data from 360,838 subjects.
methodsWe used approximate conditional analysis to adjust the results from the published GWAS for the effects of the top risk variants identified in that study. We then analyzed the adjusted GWAS results with the EUGENE gene-based approach, which combines evidence for association with disease risk across regulatory variants identified in different tissues. Novel gene-based associations were followed up in an independent sample of 233,898 subjects from the UK Biobank study.
resultsOf the 19,432 genes tested, 30 had a significant gene-based association at a Bonferroni-corrected P value of 2.5 × 10
conclusionUsing a gene-based approach, we identified 11 risk loci for allergic disease that were not reported in previous GWASs. Functional studies that investigate the contribution of the 19 associated genes to the pathophysiology of allergic disease and assess their therapeutic potential are warranted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.