ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2018
Evidence of demyelination in mild cognitive impairment and dementia using a direct and specific magnetic resonance imaging measure of myelin content.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
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109 citing papers in PubMed, 160 citations in OpenAlex.
- Review
- The shifting landscape of brain-wide myelination across the human lifespan.Nature communications · 2026Article
- Sequential associations of myelin dysfunction with Aβ and Tau pathology in Alzheimer's disease: a dynamic myelin perturbation.Alzheimer's research & therapy · 2026Article
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- Multi-omics validation of myelin water fraction as a myelin-specific MRI biomarker.NeuroImage · 2026Article
- The role of modifiable risk factors on the cerebral myelin content and cognition: findings from The Maastricht Study.GeroScience · 2026Article
- ACSS2 is essential for myelination via maintenance of the OPC population.Nature aging · 2026Article
- ACSS2 maintains oligodendrocyte progenitor cell pool and is required for myelination during development and aging.Nature aging · 2026Article
- Repeatability of Susceptibility Source Separation Methods in Human Brain: A Single-Site Study at 3 T.NMR in biomedicine · 2026Article
- From artery to memory: a comparative review of vascular cognitive impairment surgical models.Frontiers in aging neuroscience · 2026Review
- Ultra-high field brain MRI for functional neurological disorder: opportunities and challenges.NeuroImage. Clinical · 2026Review
- Vessel segmentation forMagnetic resonance in medicine · 2026Article
- Effect of Water Temperature during Aquatic Exercise on Cognitive Impairment in Mice with Chronic Cerebral Hypoperfusion.Journal of vascular research · 2026Article
- Myelin water imaging from accelerated 3D-GRASE acquisitions using subspace constrained reconstruction.Magma (New York, N.Y.) · 2025Article
- Complement dysregulation in human tauopathies.Brain pathology (Zurich, Switzerland) · 2025Article
- Lipid metabolism in microglia: Emerging mechanisms and therapeutic opportunities for neurodegenerative diseases (Review).International journal of molecular medicine · 2025Review
- Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes.Genome medicine · 2025Article
- Age-related differences in Rostral-Middle locus coeruleus microstructure: A critical role in cognitive decline revealed by magnetic resonance relaxometry.Alzheimer's research & therapy · 2025Article
- Adaptive Immune Dyshomeostasis as a Mediator of Vascular Cognitive Decline: Unraveling Neurovascular Crosstalk.Aging and disease · 2025Review
- Modulation of Sel1L can alleviate altered ER homeostasis towards white matter damage in CKD-stroke complex.Communications biology · 2025Article
49 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
introductionWe investigated brain demyelination in aging, mild cognitive impairment (MCI), and dementia using a direct magnetic resonance imaging marker of myelin.
methodsBrains of young and old controls, and old subjects with MCI, Alzheimer's disease, or vascular dementia were scanned using our recently developed myelin water fraction (MWF) mapping technique, which provides greatly improved accuracy over previous comparable methods. Maps of MWF, a direct and specific myelin measure, and relaxation times and magnetization transfer ratio, indirect and nonspecific measures, were constructed.
resultsMCI subjects showed decreased MWF compared with old controls. Demyelination was greater in Alzheimer's disease or vascular dementia. As expected, decreased MWF was accompanied by decreased magnetization transfer ratio and increased relaxation times. The young subjects showed greater myelin content than the old subjects. DISCUSSION: We believe this to be the first demonstration of myelin loss in MCI, Alzheimer's disease, and vascular dementia using a method that provides a quantitative magnetic resonance imaging-based measure of myelin. Our findings add to the emerging evidence that myelination may represent an important biomarker for the pathology of MCI and dementia. This study supports the investigation of the role of myelination in MCI and dementia through use of this quantitative magnetic resonance imaging approach in clinical studies of disease progression, and relationship of functional status to myelination status. Furthermore, mapping MWF may permit myelin to serve as a therapeutic target in clinical trials.
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