ArticleDevelopmental biology2018
Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes.
Article in Developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- The anterior hypothalamic area: a hub for convergence of innate and learned threat responding.Brain structure & function · 2026Review
- Decoding gene networks controlling hypothalamic and prethalamic neuron development.Cell reports · 2025Article
- CTNNB1 syndrome mouse models.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Decoding Gene Networks Controlling Hypothalamic and Prethalamic Neuron Development.bioRxiv : the preprint server for biology · 2025Article
- Molecular Cascades That Build and Connect Auditory Neurons from Hair Cells to the Auditory Cortex.Journal of experimental neurology · 2025Article
- Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain.Annual review of neuroscience · 2024Review
- Implication of transcription factor FOXD2 dysfunction in syndromic congenital anomalies of the kidney and urinary tract (CAKUT).Kidney international · 2024Article
- Cep120 is essential for kidney stromal progenitor cell growth and differentiation.EMBO reports · 2024Article
- Forkhead box protein D2 suppresses colorectal cancer by reprogramming enhancer interactions.Nucleic acids research · 2023Article
- A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus.eLife · 2023Article
- Article
- Developmental patterning of peptide transcription in the central circadian clock in both sexes.Frontiers in neuroscience · 2023Article
- Article
- SOX2 Regulates Neuronal Differentiation of the Suprachiasmatic Nucleus.International journal of molecular sciences · 2021Article
- Article
- Variant-to-Gene-Mapping Analyses Reveal a Role for the Hypothalamus in Genetic Susceptibility to Inflammatory Bowel Disease.Cellular and molecular gastroenterology and hepatology · 2021Article
- Genesis of the Master Circadian Pacemaker in Mice.Frontiers in neuroscience · 2021Review
- The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development.Nature communications · 2020Article
- Circuit development in the master clock network of mammals.The European journal of neuroscience · 2020Review
- Development of the basal hypothalamus through anisotropic growth.Journal of neuroendocrinology · 2019Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Although the hypothalamus functions as a master homeostat for many behaviors, little is known about the transcriptional networks that control its development. To investigate this question, we analyzed mice deficient for the Forkhead domain transcription factor Foxd1. Foxd1 is selectively expressed in neuroepithelial cells of the prethalamus and hypothalamus prior to the onset of neurogenesis, and is later restricted to neural progenitors of the prethalamus and anterior hypothalamus. During early stages of neurogenesis, we observed that Foxd1-deficient mice showed reduced expression of Six3 and Vax1 in anterior hypothalamus, but overall patterning of the prethalamus and hypothalamus is unaffected. After neurogenesis is complete, however, a progressive reduction and eventual loss of expression of molecular markers of the suprachiasmatic, paraventricular and periventricular hypothalamic is observed. These findings demonstrate that Foxd1 acts in hypothalamic progenitors to allow sustained expression of a subset of genes selectively expressed in mature neurons of the anterior hypothalamus.
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