Evidence map›Paper›PMID 29679490›Full record

ArticleClinical and experimental immunology2018

Increased natural killer cell subsets with inhibitory cytokines and inhibitory surface receptors in patients with recurrent miscarriage and decreased or normal subsets in kidney transplant recipients late post-transplant.

L Zhu, M Aly, H Wang, H Karakizlis, R Weimer, C Morath, R J Kuon, B Toth, N Ekpoom, G Opelz and 1 more

Open access · greenAbstract readComparative Study
In one paragraph

Article in Clinical and experimental immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Cellular Immunity in Chronic Kidney Disease and Changes After Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  3. Natural Killer Cell Education in Women With Recurrent Pregnancy Loss.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

L ZhuTransplantation-Immunology, Institute of Immunology, University Hospital Heidelberg, Heidelberg, Germany.
M AlyTransplantation-Immunology, Institute of Immunology, University Hospital Heidelberg, Heidelberg, Germany.
H WangDepartment of Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
H KarakizlisDepartment of Internal Medicine, University of Giessen, Giessen, Germany.
R WeimerDepartment of Internal Medicine, University of Giessen, Giessen, Germany.
C MorathDepartment of Nephrology.
R J KuonDepartment of Obstetrics and Gynecology, University Hospital Heidelberg, Heidelberg, Germany.
B TothDepartment of Gynecological Endocrinology and Reproductive Medicine, Medical University Innsbruck, Innsbruck, Austria.
N EkpoomTransplantation-Immunology, Institute of Immunology, University Hospital Heidelberg, Heidelberg, Germany.
G OpelzTransplantation-Immunology, Institute of Immunology, University Hospital Heidelberg, Heidelberg, Germany.
V DanielTransplantation-Immunology, Institute of Immunology, University Hospital Heidelberg, Heidelberg, Germany.ORCID 0000-0001-8345-1031
Heidelberg University · DEJustus-Liebig-Universität Gießen · DEInnsbruck Medical University · ATTongji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with recurrent miscarriage (RM) show up-regulated cytotoxic natural killer (NK) cells that are suspected to play a causal role in abortion. In the present study, we investigated counter-regulating inhibitory mechanisms and compared the results in RM patients with those of healthy controls (HC), patients with end-stage renal disease (ESRD) and kidney transplant recipients late post-transplant (TX). NK, NK T and T cell subsets were analysed in the peripheral blood of 31 RM, 14 female ESRD and nine female TX patients as well as 21 female HC using eight-colour fluorescence flow cytometry. Compared with HC, RM patients showed significantly higher absolute numbers of CD56

Indexed as

Kidney TransplantationAbortion, HabitualAdultAgedCytokinesFemaleFlow CytometryGraft RejectionHumansImmunophenotypingKiller Cells, NaturalLymphocyte SubsetsMiddle AgedPregnancyReceptors, Natural Killer CellTransplant RecipientsCytokinesReceptors, Natural Killer Cellinhibitory cytokinesinhibitory surface receptorskidney transplant recipients late post-transplantNK cell subsetspatients with recurrent miscarriage

Identifiers

PMID29679490
PMCPMC6046488
OpenAlexW2802418748

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.