Evidence map›Paper›PMID 29679440›Full record

ArticleAddiction (Abingdon, England)2018

Effects of a prior authorization policy for extended-release/long-acting opioids on utilization and outcomes in a state Medicaid program.

Shellie L Keast, Hyunjee Kim, Richard A Deyo, Luke Middleton, K John McConnell, Kun Zhang, Sharia M Ahmed, Nancy Nesser, Daniel M Hartung

Abstract read
In one paragraph

Article in Addiction (Abingdon, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Impact of drug utilization management policy on prescription opioid use in Georgia Medicaid.Journal of pharmaceutical health services research : an official journal of the Royal Pharmaceutical Society of Great Britain · 2021
    Article
  12. Article
  13. Misalignment of Stakeholder Incentives in the Opioid Crisis.International journal of environmental research and public health · 2020
    Review
  14. The state of the science in opioid policy research.Drug and alcohol dependence · 2020
    Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shellie L KeastUniversity of Oklahoma College of Pharmacy, Oklahoma City, OK, USA.ORCID http://orcid.org/0000-0002-9139-6105
Hyunjee KimOregon Health and Science University, Portland, OR, USA.
Richard A DeyoOregon Health and Science University, Portland, OR, USA.
Luke MiddletonOregon State University, Oregon Health and Science University, Portland, OR, USA.
K John McConnellOregon Health and Science University, Portland, OR, USA.
Kun ZhangCenters for Disease Control and Prevention, National Center for Injury Prevention and Control, Atlanta, GA, USA.
Sharia M AhmedOregon State University, Oregon Health and Science University, Portland, OR, USA.
Nancy NesserOklahoma Health Care Authority, Oklahoma City, OK, USA.
Daniel M HartungOregon Health and Science University, Portland, OR, USA.

Funding

NCIPC CDC HHS U01 CE002500
6 · The paper itself

Abstract

BACKGROUND AND

aimsIn response to the opioid overdose epidemic, US state Medicaid programs have adopted restrictive policies for opioid analgesics, yet effects on prescribing patterns and health outcomes are uncertain. This study aimed to examine effects of a prior authorization policy for extended-release/long-acting (ER/LA) opioids on opioid use in the Oklahoma, USA state Medicaid program.

designRetrospective difference-in-differences design study comparing changes in opioid use in Oklahoma Medicaid to control (Oregon Medicaid).

settingOklahoma and Oregon, USA.

participantsMedicaid beneficiaries in the Oklahoma and Oregon fee-for-service Medicaid programs between July 2007 and June 2009 (33 724 in Oklahoma and 13 520 in Oregon) MEASUREMENTS: The primary outcome was incident opioid-naive ER/LA opioid use. Secondary outcomes included other opioid and non-opioid pain medication use. We also examined indicators of high-risk prescribing (e.g. high-dosage opioid use) and opioid-related hospitalizations or emergency department (ED) visits.

findingsThe prior authorization policy was associated with a 0.7 percentage point reduction in the likelihood of incident opioid-naive ER/LA opioid use [95% confidence interval (CI) = -1.16 to -0.33 percentage points; 70% pre-policy mean reduction, a 1.4 percentage point decrease in likelihood of any new ER/LA opioid prescriptions (95% CI = -2.1 to -0.7 percentage points; 33% pre-policy mean reduction) and a decline of 0.16 in total ER/LA opioid prescriptions per enrollee (PPE) (95% CI = -0.29 to -0.04 PPE)]. There was a significant increase in the number of short-acting opioids filled after the policy (0.36; 95% CI = 0.22-0.50 PPE), increases in likelihood of having overlapping opioids and benzodiazepines, but significant reductions in likelihood of having overlapping opioids. No significant changes in opioid-related hospitalizations or ED visits were observed.

conclusionsIn Oklahoma, USA's July 2008 prior authorization policy for extended-release/long-acting opioids appears to have reduced the number of opioid-naive patients initiating extended-release/long-acting opioid use by more than half, but may also have increased short-acting opioid prescriptions by 7%.

Indexed as

AnalgesicsbenzodiazepinesMedicaidopioidopioid-related disorderspainretrospective studies

Identifiers

PMID29679440
PMCPMC9926938

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.