ArticleNeuropathology and applied neurobiology2019
Prominent microglial activation in cortical white matter is selectively associated with cortical atrophy in primary progressive aphasia.
Article in Neuropathology and applied neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Alzheimer's disease clinical variants show distinct neuroinflammatory profiles with neuropathology.Neuropathology and applied neurobiology · 2024Article
- Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity.Neurobiology of aging · 2023Article
- The relationship between TLR4/NF-κB/IL-1β signaling, cognitive impairment, and white-matter integrity in patients with stable chronic schizophrenia.Frontiers in psychiatry · 2022Article
- Accumulation of neurofibrillary tangles and activated microglia is associated with lower neuron densities in the aphasic variant of Alzheimer's disease.Brain pathology (Zurich, Switzerland) · 2021Article
- Primary Progressive Aphasia has a Unique Signature Distinct from Dementia of the Alzheimer's Type and Behavioral Variant Frontotemporal Dementia Regardless of Pathology.Journal of neuropathology and experimental neurology · 2020Article
- Microglial burden, activation and dystrophy patterns in frontotemporal lobar degeneration.Journal of neuroinflammation · 2020Article
- Neuropathologic basis of in vivo cortical atrophy in the aphasic variant of Alzheimer's disease.Brain pathology (Zurich, Switzerland) · 2020Article
- Distribution of microglial phenotypes as a function of age and Alzheimer's disease neuropathology in the brains of people with Down syndrome.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Cerebrospinal Fluid YKL-40 and Chitotriosidase Levels in Frontotemporal Dementia Vary by Clinical, Genetic and Pathological Subtype.Dementia and geriatric cognitive disorders · 2020Article
- Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.Acta neuropathologica · 2019Article
- Activated Microglia in Cortical White Matter Across Cognitive Aging Trajectories.Frontiers in aging neuroscience · 2019Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
aimsPrimary progressive aphasia (PPA) is a clinical syndrome characterized by selective language impairments associated with focal cortical atrophy favouring the language dominant hemisphere. PPA is associated with Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD) and significant accumulation of activated microglia. Activated microglia can initiate an inflammatory cascade that may contribute to neurodegeneration, but their quantitative distribution in cortical white matter and their relationship with cortical atrophy remain unknown. We investigated white matter activated microglia and their association with grey matter atrophy in 10 PPA cases with either AD or FTLD-TDP pathology.
methodsActivated microglia were quantified with optical density measures of HLA-DR immunoreactivity in two regions with peak cortical atrophy, and one nonatrophied region within the language dominant hemisphere of each PPA case. Nonatrophied contralateral homologues of the language dominant regions were examined for hemispheric asymmetry.
resultsQualitatively, greater densities of activated microglia were observed in cortical white matter when compared to grey matter. Quantitative analyses revealed significantly greater densities of activated microglia in the white matter of atrophied regions compared to nonatrophied regions in the language dominant hemisphere (P < 0.05). Atrophied regions of the language dominant hemisphere also showed significantly more activated microglia compared to contralateral homologues (P < 0.05).
conclusionsWhite matter activated microglia accumulate more in atrophied regions in the language dominant hemisphere of PPA. While microglial activation may constitute a response to neurodegenerative processes in white matter, the resultant inflammatory processes may also exacerbate disease progression and contribute to cortical atrophy.
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