Evidence map›Paper›PMID 29679296›Full record

ArticlePflugers Archiv : European journal of physiology2018

Methylmercury reduces synaptic transmission and neuronal excitability in rat hippocampal slices.

J Gutiérrez, A M Baraibar, E Albiñana, P Velasco, J M Solís, J M Hernández-Guijo

Abstract read
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In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

J GutiérrezDepartment of Pharmacology and Therapeutic, Universidad Autónoma de Madrid, IRYCIS, Av. Arzobispo Morcillo 4, 28029, Madrid, Spain.
A M BaraibarDepartment of Pharmacology and Therapeutic, Universidad Autónoma de Madrid, IRYCIS, Av. Arzobispo Morcillo 4, 28029, Madrid, Spain.
E AlbiñanaDepartment of Pharmacology and Therapeutic, Universidad Autónoma de Madrid, IRYCIS, Av. Arzobispo Morcillo 4, 28029, Madrid, Spain.
P VelascoDepartment of Pharmacology and Therapeutic, Universidad Autónoma de Madrid, IRYCIS, Av. Arzobispo Morcillo 4, 28029, Madrid, Spain.
J M SolísServicio de Neurobiología-Investigación, Hospital Universitario Ramón y Cajal, IRYCIS, 28034, Madrid, Spain.
J M Hernández-GuijoDepartment of Pharmacology and Therapeutic, Universidad Autónoma de Madrid, IRYCIS, Av. Arzobispo Morcillo 4, 28029, Madrid, Spain. jesusmiguel.hernandez@uam.es.
Universidad Autónoma de Madrid · ESInstituto Ramón y Cajal de Investigación Sanitaria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a previous study, we pointed out that the neurotoxic action evoked by methylmercury (MeHg), a potent environmental pollutant responsible for fatal food poisoning, is associated with alterations of cellular excitability by irreversible blockade of sodium and calcium currents. Here, we investigated the MeHg effects on synaptic transmission and neuronal plasticity using extracellular field recording in CA1 area of rat hippocampal slices. MeHg caused a fast and drastic depression of evoked field excitatory postsynaptic potentials (fEPSPs) in a concentration-dependent manner with an IC

Indexed as

AnimalsElectric StimulationExcitatory Postsynaptic PotentialsHippocampusLong-Term PotentiationMaleMethylmercury CompoundsNeuronal PlasticityNeuronsRatsRats, Sprague-DawleySynaptic TransmissionTemporal LobeMethylmercury CompoundsfEPSPHippocampal slicesIntrinsic excitabilityMethylmercuryPopulation spikesSynaptic transmission

Identifiers

PMID29679296
OpenAlexW2801120837

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.