Evidence map›Paper›PMID 29679228›Full record

Observational studyClinical oral investigations2019

Recovery time after oral and maxillofacial ambulatory surgery with dexmedetomidine: an observational study.

Belen Hernando, Antonio Martinez-Simon, Elena Cacho-Asenjo, Iñaki F Troconiz, Cristina Honorato-Cia, Alfredo Panadero, Luis L Naval, Jorge M Nuñez-Cordoba

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Belen HernandoDepartment of Anesthesia, Perioperative Medicine and Critical Care, University of Navarra Clinic, Pio XII n° 36, 31008, Pamplona, Spain. bhvela1@gmail.com.ORCID http://orcid.org/0000-0002-0442-958X
Antonio Martinez-SimonDepartment of Anesthesia, Perioperative Medicine and Critical Care, University of Navarra Clinic, Pio XII n° 36, 31008, Pamplona, Spain.
Elena Cacho-AsenjoDepartment of Anesthesia, Perioperative Medicine and Critical Care, University of Navarra Clinic, Pio XII n° 36, 31008, Pamplona, Spain.
Iñaki F TroconizPharmacometrics & Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
Cristina Honorato-CiaDepartment of Anesthesia, Perioperative Medicine and Critical Care, University of Navarra Clinic, Pio XII n° 36, 31008, Pamplona, Spain.
Alfredo PanaderoDepartment of Anesthesia, Perioperative Medicine and Critical Care, University of Navarra Clinic, Pio XII n° 36, 31008, Pamplona, Spain.
Luis L NavalDepartment of Oral and Maxillofacial Surgery, University of Navarra Clinic, Pamplona, Spain.
Jorge M Nuñez-CordobaResearch Support Service, Central Clinical Trials Unit, University of Navarra Clinic, Pamplona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the relationship between pharmacokinetic descriptors of dexmedetomidine (predicted area under the curve during the procedure, predicted plasma level at the end of the procedure, and duration of procedure) and sedation depth (proportion of time with bispectral index < 85 during the procedure) with recovery time after ambulatory procedures. MATERIALS AND

methodsClinical observational study of patients undergoing oral and maxillofacial ambulatory surgery with dexmedetomidine as sole sedative agent. Patients received a loading dose of dexmedetomidine (0.25-1 μg kg

resultsData from 75 patients was analyzed. Sedation depth was directly associated with recovery time (Pearson correlation coefficient [r] = 0.26; p = 0.024). Around 7% of the variation in recovery time was explained by the proportion of time with bispectral index < 85. No association with procedure duration (r = 0.01; p = 0.9), predicted area under the curve (r = 0.1; p = 0.4), or predicted plasma level of dexmedetomidine at the end of the procedure (r = 0.12; p = 0.3) with recovery time was observed.

conclusionsSedation depth with dexmedetomidine could play a role in increasing recovery time after oral and maxillofacial ambulatory surgery. In our study, the pharmacokinetic descriptors of dexmedetomidine did not seem to influence recovery time. CLINICAL RELEVANCE: Sedation depth with dexmedetomidine could play a role in increasing recovery time after ambulatory procedures.

Indexed as

Ambulatory Surgical ProceduresAnesthesia Recovery PeriodOral Surgical ProceduresAdultDexmedetomidineFemaleHumansHypnotics and SedativesMaleDexmedetomidineHypnotics and SedativesBispectral indexDexmedetomidineOral and maxillofacial ambulatory surgeryRecovery timeSedation

Identifiers

PMID29679228

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.