SynthesisForensic science, medicine, and pathology2018
Diagnostic role of serum tryptase in anaphylactic deaths in forensic medicine: a systematic review and meta-analysis.
Synthesis in Forensic science, medicine, and pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Beyond the numbers: Critical analysis of the role of postmortem tryptase in the forensic diagnosis of anaphylaxis.Journal of forensic sciences · 2025Pooled it
- Diagnostic Roles of Postmortem cTn I and cTn T in Cardiac Death with Special Regard to Myocardial Infarction: A Systematic Literature Review and Meta-Analysis.International journal of molecular sciences · 2019Pooled it
- Triggers, Types, and Treatments for Kounis Syndrome: A Systematic Review.Clinics and practice · 2025Review
- Tryptase: The Silent Witness of Past and Ongoing Systemic Events.Medicina (Kaunas, Lithuania) · 2024Review
- Anaphylactic deaths: A retrospective study of forensic autopsy cases from 2009 to 2019 in Shanghai, China.Heliyon · 2024Article
- The 2020 update on anaphylaxis in paediatric population.Postepy dermatologii i alergologii · 2022Review
- Fatal anaphylaxis due to peanut exposure from oral intercourse.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021Article
- Postmortem diagnostics of assumed suicidal food anaphylaxis in prison: a unique case of anaphylactic death due to peach ingestion.Forensic science, medicine, and pathology · 2021Article
- State-of-the-Art on Biomarkers for Anaphylaxis in Obstetrics.Life (Basel, Switzerland) · 2021Review
- Interference of hemolysis on the postmortem biochemical analysis of IgE by ECLIA.International journal of legal medicine · 2021Article
- Anaphylactic Death: A New Forensic Workflow for Diagnosis.Healthcare (Basel, Switzerland) · 2021Article
- Reliable Postmortem Molecular Diagnosis of Anaphylaxis: Co-localization of Mast Cell Degranulation and Immunoglobulin E in Allergic Throat Tissues.The American journal of forensic medicine and pathology · 2020Article
- "Diagnostic role of serum tryptase in anaphylactic deaths in forensic medicine: a systematic review and meta-analysis" should be re-calibrated and re-edited.Forensic science, medicine, and pathology · 2019Article
- The effects of different sampling techniques on peripheral post mortem tryptase levels: a recommended sampling method.International journal of legal medicine · 2019Article
- Biomarkers in Human Anaphylaxis: A Critical Appraisal of Current Evidence and Perspectives.Frontiers in immunology · 2019Review
- Fatal food-induced anaphylaxis: Determination of tryptase and specific IgE on cadaveric blood samples. What else for a better methodological standard?International journal of immunopathology and pharmacologyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Postmortem diagnosis of sudden death due to anaphylaxis can be very difficult due to the non-specific pathological findings in forensic practice. Postmortem serum tryptase has been used as an indicator of possible ante-mortem anaphylaxis. Though many previous studies have been conducted to explore the diagnostic significance of serum tryptase for lethal anaphylaxis, inconsistent results were documented. In this study, we made a retrospective study and presented a systematic review and meta-analysis that aims to summarize the diagnostic significance of postmortem serum tryptase in the deceased with and without anaphylactic shock and to calculate a cutoff value for future reference in the identification of deaths due to anaphylactic shock. A complete literature search in the PubMed, Cochrane Library, CNKI and Embase databases (published prior to March 1st, 2017) was performed. The quality of the eligible literature was evaluated according to the Newcastle-Ottawa Quality Assessment Scale (NOS), and the relevant data was extracted. The procedure of meta-analysis was performed by RevMan 5.3 software. Subgroup analysis was performed according to different causes of death. A total of nine studies with 296 patients were identified. The NOS of each included study was equal to 7. The results indicated that high concentrations of tryptase were significantly associated with anaphylactic shock when compared to the other causes of death. The weighted mean difference (WMD) was 29.53 (95% CI = 7.58-51.47, p = 0.008). Similar results were detected in the subgroup analysis when compared to deaths due to cardiovascular disease (CVD). However, no obvious elevation of tryptase in decedents with CVD compared to the other cause of death was observed (WMD = 4.42, 95% CI = -0.94-9.79). We concluded that high serum tryptase is a promising diagnostic biomarker for deaths due to anaphylactic shock, especially when it is higher than 30.4 μg/L.
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