Evidence map›Paper›PMID 29679193›Full record

ArticleBehavior genetics2018

Etiology of Stability and Growth of Internalizing and Externalizing Behavior Problems Across Childhood and Adolescence.

Alexander S Hatoum, Soo Hyun Rhee, Robin P Corley, John K Hewitt, Naomi P Friedman

Abstract readTwin Study
In one paragraph

Article in Behavior genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexander S HatoumDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA. alexander.hatoum@colorado.edu.
Soo Hyun RheeDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado Boulder, 447 UCB, Boulder, CO, 80309, USA.
John K HewittDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Naomi P FriedmanDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.

Funding

Colorado Adoption/Twin Study of Lifespan behavioral development & cognitive aging (CATSLife2)R01AG046938 · NIA · UNIVERSITY OF COLORADO · PI REYNOLDS, CHANDRA A, WADSWORTH, SALLY J · 2015 to 2024
$18.5M
Neural Substrates of Executive Function: An fMRI Twin StudyR01MH063207 · NIMH · UNIVERSITY OF COLORADO AT BOULDER · PI FRIEDMAN, NAOMI P. · 2001 to 2018
$6.5M
Research Training: Mental Health Behavior GeneticsT32MH016880 · NIMH · UNIVERSITY OF COLORADO AT BOULDER · PI Naomi P. Friedman, Matthew Charles Keller · 1985 to 2026
$5.3M
DETERMINANTS OF BEHAVIORAL DEVELOPMENT IN CHILDRENR01HD010333 · NICHD · UNIVERSITY OF COLORADO AT BOULDER · PI WADSWORTH, SALLY J · 1985 to 2010
$3.0M
Executive Functions and Self-Regulation: A Twin StudyR56MH063207 · NIMH · UNIVERSITY OF COLORADO · PI HEWITT, JOHN K. · 2007 to 2007
$490k
National Institute of Mental Health (US) HD010333NIA NIH HHS R01 AG046938NICHD NIH HHS R01 HD010333NIMH NIH HHS AG046938NIMH NIH HHS MH016880NIMH NIH HHS MH063207NIMH NIH HHS R01 MH063207NIMH NIH HHS R56 MH063207NIMH NIH HHS T32 MH016880
6 · The paper itself

Abstract

Internalizing and externalizing behaviors are heritable, and show genetic stability during childhood and adolescence. Less work has explored how genes influence individual differences in developmental trajectories. We estimated ACE biometrical latent growth curve models for the Teacher Report Form (TRF) and parent Child Behavior Checklist (CBCL) internalizing and externalizing scales from ages 7 to 16 years in 408 twin pairs from the Colorado Longitudinal Twin Study. We found that Intercept factors were highly heritable for both internalizing and externalizing behaviors (a2 = .61-.92), with small and nonsignificant environmental influences for teacher-rated data but significant nonshared environmental influences for parent-rated data. There was some evidence of heritability of decline in internalizing behavior (Slopes for teacher and parent ratings), but the Slope genetic variance was almost entirely shared with that for the Intercept when different than zero. These results suggest that genetic effects on these developmental trajectories operate primarily on initial levels and stability, with no significant unique genetic influences for change. Finally, cross-rater analyses of the growth factor scores revealed moderate to large genetic and environmental associations between growth factors derived from parents' and teachers' ratings, particularly the Intercepts.

Indexed as

AdolescentChildChild Behavior DisordersFemaleHumansMaleModels, BiologicalParentsPhenotypeSample SizeTwinsExternalizing behaviorHeritabilityInternalizing behaviorLatent growth curvesTrajectoriesTwins

Identifiers

PMID29679193
PMCPMC6026557

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.