ArticleJournal of perinatology : official journal of the California Perinatal Association2018
A quality improvement initiative to reduce necrotizing enterocolitis across hospital systems.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Quality improvement interventions to prevent neonatal necrotizing enterocolitis: a systematic review.Frontiers in pediatrics · 2025Pooled it
- Early erythropoietin for preventing necrotizing enterocolitis in preterm neonates - an updated meta-analysis.European journal of pediatrics · 2022Pooled it
- Probiotic supplementation in very low birth weight infants: A single center experience in safety, tolerability, and necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Unplanned natural experiment: probiotics prevent necrotizing enterocolitis, a single center quality improvement report.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Early childhood growth following prenatal opioid exposure and Neonatal Opioid Withdrawal Syndrome.Pediatric research · 2025Article
- Standardizing feeding strategies for preterm infants born greater than 1500 grams.Pediatric research · 2025Article
- Quality Improvement Project to Improve Adherence to Best Practices to Decrease Incidence of Necrotizing Enterocolitis in Preterm Infants.Children (Basel, Switzerland) · 2025Article
- A Multi-Center Survey of Necrotizing Enterocolitis Prevention Strategies in Very Low Birth Weight Infants.Pediatric health, medicine and therapeutics · 2025Article
- Sodium formate induces development-dependent intestinal epithelial injury via necroptosis and apoptosis.Redox report : communications in free radical research · 2024Article
- Effects of Early Enteral to Parenteral Protein Ratios on Brain Volume and Somatic Growth in Very Low Birth Weight Infants.The Journal of pediatrics · 2024Article
- A pilot study of fecal pH and redox as functional markers in the premature infant gut microbiome.PloS one · 2024Article
- Key biologically active components of breast milk and their beneficial effects.Seminars in pediatric surgery · 2023Review
- Butyrate induces development-dependent necrotizing enterocolitis-like intestinal epithelial injury via necroptosis.Pediatric research · 2023Article
- Operation Status of the Mutual Aid Human Milk Bank for Preterm Infants and Data Analysis.Journal of multidisciplinary healthcare · 2023Article
- Advancements in neonatology through quality improvement.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
- Standardizing the Evaluation and Management of Necrotizing Enterocolitis in a Level IV NICU.Pediatrics · 2022Article
- Delay in achieving enteral autonomy and growth outcomes in very low birth weight infants with surgical necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Racial/ethnic disparities and human milk use in necrotizing enterocolitis.Pediatric research · 2020Article
- Grading the evidence to identify strategies to modify risk for necrotizing enterocolitis.Pediatric research · 2020Review
- Implementation of a probiotic protocol to reduce rates of necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNecrotizing enterocolitis (NEC) is a devastating intestinal disease in premature infants. Local rates of NEC were unacceptably high. We hypothesized that utilizing quality improvement methodology to standardize care and apply evidence-based practices would reduce our rate of NEC. STUDY
designA multidisciplinary team used the model for improvement to prioritize interventions. Three neonatal intensive care units (NICUs) developed a standardized feeding protocol for very low birth weight (VLBW) infants, and employed strategies to increase the use of human milk, maximize intestinal perfusion, and promote a healthy microbiome.
resultsThe primary outcome measure, NEC in VLBW infants, decreased from 0.17 cases/100 VLBW patient days to 0.029, an 83% reduction, while the compliance with a standardized feeding protocol improved.
conclusionThrough reliable implementation of evidence-based practices, this project reduced the regional rate of NEC by 83%. A key outcome and primary driver of success was standardization across multiple NICUs, resulting in consistent application of best practices and reduction in variation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.