ArticleScientific reports2018
Combining electrical stimulation and tissue engineering to treat large bone defects in a rat model.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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Who cites it
94 citing papers in PubMed.
- Direct and Gradual Electrical Testicular Shocks Stimulate Spermatogenesis and Activate Sperms in Infertile Men: A Randomized Controlled Trial.American journal of men's healthTrial
- In-situ Damascus-patterning enables tunable surface electric fields for bioactive titanium implants.Bioactive materials · 2026Article
- Engineering Smart Scaffolds for Osteomyelitis: Integrating Nanotechnology, Drug Delivery, and Tissue Regeneration-A Narrative Review.Journal of functional biomaterials · 2026Review
- Reconstructing the ischemic osteogenic microenvironment through hierarchical scaffolds orchestrating MgBioactive materials · 2026Article
- Perioperative Applications of Electrical Stimulation in Flap Surgeries: Mechanisms and Benefits.Advances in skin & wound care · 2026Review
- Evolutionary applications of electrical stimulation in bone repair: bibliometric trends and temporal dynamics.EFORT open reviews · 2026Review
- Electrical Stimulation Directs Formation of Perfused Vasculature in Engineered Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation.Journal of biomedical materials research. Part B, Applied biomaterials · 2026Review
- Clinical Applications of Biophysical Stimuli Technologies for Bone Healing.Annals of biomedical engineering · 2026Review
- In vitro electrical stimulation devices: practical framework for design, fabrication, and operation.Journal of biological engineering · 2026Article
- Modular bioreactor for multi-well electrical stimulation ofLab on a chip · 2026Article
- Electric field stimulation-responsive hydrogels for bone regeneration: from mechanisms to applications.Bone research · 2026Review
- Biodegradable piezoelectric PHB-BT nanofiber scaffolds combined with ultrasound stimulation to accelerate bone regeneration by regulating CaTheranostics · 2026Article
- Parameter-resolved AC electrical stimulation links electrical system characteristics to early transcriptional responses in human stem cells.Frontiers in bioengineering and biotechnology · 2026Article
- Alternating Current Stimulation Promotes Healing of Bone Fractures in Rabbits.Bioengineering (Basel, Switzerland) · 2025Article
- Review
- The Effect of Electrical Stimulation on the Cellular Response of Human Mesenchymal Stem Cells Grown on Silicon Carbide-Coated Carbon Nanowall Scaffolds.Bioengineering (Basel, Switzerland) · 2025Article
- Review
- Electrical Stimulation Therapy - Dedicated to the Perfect Plastic Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Accelerated Bone Healing via Electrical Stimulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
34 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone Tissue engineering (BTE) has recently been introduced as an alternative to conventional treatments for large non-healing bone defects. BTE approaches mimic autologous bone grafts, by combining cells, scaffold, and growth factors, and have the added benefit of being able to manipulate these constituents to optimize healing. Electrical stimulation (ES) has long been used to successfully treat non-healing fractures and has recently been shown to stimulate bone cells to migrate, proliferate, align, differentiate, and adhere to bio compatible scaffolds, all cell behaviors that could improve BTE treatment outcomes. With the above in mind we performed in vitro experiments and demonstrated that exposing Mesenchymal Stem Cells (MSC) + scaffold to ES for 3 weeks resulted in significant increases in osteogenic differentiation. Then in in vivo experiments, for the first time, we demonstrated that exposing BTE treated rat femur large defects to ES for 8 weeks, caused improved healing, as indicated by increased bone formation, strength, vessel density, and osteogenic gene expression. Our results demonstrate that ES significantly increases osteogenic differentiation in vitro and that this effect is translated into improved healing in vivo. These findings support the use of ES to help BTE treatments achieve their full therapeutic potential.
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