Evidence map›Paper›PMID 29679008›Full record

ArticleNature communications2018

Improving wood properties for wood utilization through multi-omics integration in lignin biosynthesis.

Jack P Wang, Megan L Matthews, Cranos M Williams, Rui Shi, Chenmin Yang, Sermsawat Tunlaya-Anukit, Hsi-Chuan Chen, Quanzi Li, Jie Liu, Chien-Yuan Lin and 27 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 263 citations in OpenAlex.

  1. Integrative Techniques for Hybrid Breeding inPlants (Basel, Switzerland) · 2026
    Review
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  5. Factors underlying a latitudinal gradient in the S/G lignin monomer ratio in natural poplar variants.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
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  14. Article
  15. Review
  16. Article
  17. Synthetic biology in plants.Plant biotechnology (Tokyo, Japan) · 2024
    Article
  18. Article
  19. Review
  20. Ectopic Expression ofInternational journal of molecular sciences · 2024
    Article

55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 8 institutions in 3 countries.

Jack P WangState Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China.
Megan L MatthewsElectrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27695, USA.
Cranos M WilliamsElectrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27695, USA.
Rui ShiForest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.
Chenmin YangForest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.
Sermsawat Tunlaya-AnukitForest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.
Hsi-Chuan ChenForest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.
Quanzi LiState Key Laboratory of Tree Genetics and Breeding, Chinese Academy of Forestry, Beijing, 100091, China.
Jie LiuForest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.
Chien-Yuan LinForest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.
Punith NaikCivil, Construction and Environmental Engineering, North Carolina State University, Raleigh, NC, 27695, USA.
Ying-Hsuan SunDepartment of Forestry, National Chung-Hsing University, Taichung, 40227, Taiwan.
Philip L LoziukDepartment of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695, USA.
Ting-Feng YehSchool of Forestry and Resource Conservation, National Taiwan University, Taipei, 10617, Taiwan.
Hoon KimDepartment of Biochemistry, and the DOE Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin, Madison, WI, 53726, USA.ORCID http://orcid.org/0000-0001-7425-7464
Erica GjersingNational Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, 80401, USA.
Todd ShollenbergerNational Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, 80401, USA.
Christopher M ShufordDepartment of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695, USA.
Jina SongElectrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27695, USA.ORCID http://orcid.org/0000-0002-9931-1129
Zachary MillerDepartment of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA.
Yung-Yun HuangDepartment of Operations Research, North Carolina State University, Raleigh, NC, 27695, USA.
Charles W EdmundsDepartment of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA.
Baoguang LiuDepartment of Forestry, Beihua University, Jilin, 132013, China.
Yi SunState Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China.
Ying-Chung Jimmy LinState Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China.
Wei LiState Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China.
Hao ChenForest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.
Ilona PeszlenDepartment of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA.
Joel J DucosteCivil, Construction and Environmental Engineering, North Carolina State University, Raleigh, NC, 27695, USA.
John RalphDepartment of Biochemistry, and the DOE Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin, Madison, WI, 53726, USA.ORCID http://orcid.org/0000-0002-6093-4521
Hou-Min ChangDepartment of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA.
David C MuddimanDepartment of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695, USA.
Mark F DavisJoint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA, 94608, USA.ORCID http://orcid.org/0000-0003-4541-9852
Chris SmithBioinformatics Research Center, North Carolina State University, Raleigh, NC, 27695, USA.
Fikret IsikDepartment of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.
Ronald SederoffForest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.
Vincent L ChiangState Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China. vchiang@ncsu.edu.
North Carolina State University · USNational Chung Hsing University · TWNational Laboratory of the Rockies · USUniversity of Wisconsin–Madison · USBeihua University · CNChinese Academy of Forestry · CNLawrence Berkeley National Laboratory · USNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A multi-omics quantitative integrative analysis of lignin biosynthesis can advance the strategic engineering of wood for timber, pulp, and biofuels. Lignin is polymerized from three monomers (monolignols) produced by a grid-like pathway. The pathway in wood formation of Populus trichocarpa has at least 21 genes, encoding enzymes that mediate 37 reactions on 24 metabolites, leading to lignin and affecting wood properties. We perturb these 21 pathway genes and integrate transcriptomic, proteomic, fluxomic and phenomic data from 221 lines selected from ~2000 transgenics (6-month-old). The integrative analysis estimates how changing expression of pathway gene or gene combination affects protein abundance, metabolic-flux, metabolite concentrations, and 25 wood traits, including lignin, tree-growth, density, strength, and saccharification. The analysis then predicts improvements in any of these 25 traits individually or in combinations, through engineering expression of specific monolignol genes. The analysis may lead to greater understanding of other pathways for improved growth and adaptation.

Indexed as

Gene Expression Regulation, PlantLigninPlants, Genetically ModifiedPopulusTranscriptomeTreesWoodXylemLignin

Identifiers

PMID29679008
PMCPMC5910405
OpenAlexW2800729007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.