Evidence map›Paper›PMID 29678998›Full record

ArticleJournal of the American Society of Nephrology : JASN2018

Acid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling Pathways.

Miriam Zacchia, Xuefei Tian, Enrica Zona, Robert J Alpern, Patricia A Preisig

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. p90RSK modulates inter-and intracellular signaling in kidney diseases.Frontiers in cell and developmental biology · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Regulation of renal NaDC1 expression and citrate excretion by NBCe1-A.American journal of physiology. Renal physiology · 2019
    Article
  9. Role of p90RSK in Kidney and Other Diseases.International journal of molecular sciences · 2019
    Review
  10. Review
  11. Acidosis and citrate: provocative interactions.Annals of translational medicine · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Miriam ZacchiaDivision of Nephrology, Department of Cardio-Thoracic and Respiratory Sciences, University of Campania "Luigi Vanvitelli," Naples, Italy; and miriamzacchia@virgilio.it.
Xuefei TianSection of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Enrica ZonaDivision of Nephrology, Department of Cardio-Thoracic and Respiratory Sciences, University of Campania "Luigi Vanvitelli," Naples, Italy; and.
Robert J AlpernSection of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Patricia A PreisigSection of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Yale University · USUniversity of Campania "Luigi Vanvitelli" · IT

Funding

REGULATION OF RENAL BICARBONATE AND CHLORIDE ABSORPTIONR01DK039298 · NIDDK · YALE UNIVERSITY · PI ALPERN, ROBERT J · 1987 to 2009
$2.0M
REGULATION OF RENAL BICARBONATE AND CHLORIDE ABSORPTIONR37DK039298 · NIDDK · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI ALPERN, ROBERT J · 1996 to 2003
$1.6M
NIDDK NIH HHS R01 DK039298NIDDK NIH HHS R37 DK039298
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MAP Kinase Signaling SystemAcidsAmmonium ChlorideAnimalsCells, CulturedCitric AcidCSK Tyrosine-Protein KinaseDicarboxylic Acid TransportersEndothelin-1Epithelial CellsFocal Adhesion Kinase 2Kidney Tubules, ProximalMiceMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3AcidsAmmonium ChlorideCitric AcidCSK Tyrosine-Protein KinaseDicarboxylic Acid TransportersEndothelin-1Focal Adhesion Kinase 2Mitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Organic Anion Transporters, Sodium-DependentProto-Oncogene Proteins c-rafPtk2b protein, mouseReceptor, Endothelin BRibosomal Protein S6 Kinases, 90-kDasrc-Family KinasesCell Signalingchronic metabolic acidosisET-1/ETB signallingNaDC-1urinary citrate

Identifiers

PMID29678998
PMCPMC6054333
OpenAlexW2801736132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.