Evidence map›Paper›PMID 29678951›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Cyclooxygenase-1 and -2 Play Contrasting Roles in

Erin Theisen, Courtney E McDougal, Masako Nakanishi, David M Stevenson, Daniel Amador-Noguez, Daniel W Rosenberg, Laura J Knoll, John-Demian Sauer

Abstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Current clinical microbiology reports · 2019
    Article
  8. Article
  9. Innate and Adaptive Immune Responses duringMicrobiology spectrum · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Erin TheisenDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706.
Courtney E McDougalDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706.
Masako NakanishiCenter for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030; and.
David M StevensonDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706.
Daniel Amador-NoguezDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706.
Daniel W RosenbergCenter for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030; and.ORCID 0000-0003-2897-2613
Laura J KnollDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706.
John-Demian SauerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706; sauer3@wisc.edu.ORCID 0000-0001-9367-794X
University of Wisconsin–Madison · USUConn Health · US

Funding

INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
Modulating the Inflammasome to Generate Robust Cell Mediated ImmunityR01CA188034 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SAUER, JOHN-DEMIAN · 2015 to 2019
$1.7M
Cell-Mediated Immunity Following Listeria monocytogenes Induced Inflammasome ActivationF30CA210912 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI THEISEN, ERIN MARIE · 2016 to 2018
$100k
NCI NIH HHS F30 CA210912NCI NIH HHS R01 CA188034NIGMS NIH HHS T32 GM008692
6 · The paper itself

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity and are commonly used for pain relief and fever reduction. NSAIDs are used following childhood vaccinations and cancer immunotherapies; however, how NSAIDs influence the development of immunity following these therapies is unknown. We hypothesized that NSAIDs would modulate the development of an immune response to

Indexed as

AcetaminophenAnimalsAnti-Inflammatory Agents, Non-SteroidalCD8-Positive T-LymphocytesCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 InhibitorsDinoprostoneFemaleImmunityImmunity, InnateListeria monocytogenesListeriosisMaleMembrane ProteinsMiceAcetaminophenAnti-Inflammatory Agents, Non-SteroidalCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 InhibitorsDinoprostoneMembrane ProteinsPtgs1 protein, mouse

Identifiers

PMID29678951
PMCPMC5964023
OpenAlexW2802224576

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.