ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Rapid Disinhibition by Adjustment of PV Intrinsic Excitability during Whisker Map Plasticity in Mouse S1.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed, 93 citations in OpenAlex.
- Convergent Inhibitory Cortical Circuit Disruption Drives Genetically Distinct Absence Seizures.bioRxiv : the preprint server for biology · 2026Article
- Synaptic zinc plasticity shapes adaptive and maladaptive cortical plasticity following cochlear injury.Science advances · 2026Article
- Postnatal Development of Pyramidal Neurons Excitability and Synaptic Inputs in Mouse Gustatory Cortical Circuits.eNeuro · 2026Article
- Conflicting adaptations in an inhibitory feedback circuit.The Journal of physiology · 2026Article
- A silent Kv channel subunit shapes PV neuron action potential waveform and short-term synaptic plasticity during high-frequency firing.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A silent Kv channel subunit shapes PV neuron action potential waveform and short-term synaptic plasticity during high-frequency firing.bioRxiv : the preprint server for biology · 2025Article
- Degraded sensory coding in a mouse model ofbioRxiv : the preprint server for biology · 2025Article
- Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells.The Journal of physiology · 2025Article
- Postnatal development of pyramidal neurons excitability and synaptic inputs in mouse gustatory cortical circuits.bioRxiv : the preprint server for biology · 2025Article
- Experience-Dependent Intrinsic Plasticity in Layer IV of Barrel Cortex at Whisking Onset.eNeuro · 2025Article
- Interactions between homeostatic plasticity and statistical learning: A role for inhibition.Current opinion in neurobiology · 2025Review
- Differential Modulation of Dopamine D2 Receptor on Somatostatin and Parvalbumin Interneurons in the CA1 Area of the Dorsal Hippocampus.The European journal of neuroscience · 2025Article
- Dynamic recruitment of PV interneurons in the somatosensory cortex induced by experience dependent plasticity.bioRxiv : the preprint server for biology · 2025Article
- Unreliable homeostatic action potential broadening in cultured dissociated neurons.bioRxiv : the preprint server for biology · 2025Article
- Molecular states underlying neuronal cell type development and plasticity in the postnatal whisker cortex.PLoS biology · 2025Article
- Immediately following the onset of active whisking, the input layer of barrel cortex exhibits a transient period of increased excitability that depends on prior experience.bioRxiv : the preprint server for biology · 2025Article
- Hibernation reduces GABA signaling in the brainstem to enhance motor activity of breathing at cool temperatures.BMC biology · 2024Article
- Hibernation reduces GABA signaling in the brainstem to enhance motor activity of breathing at cool temperatures.bioRxiv : the preprint server for biology · 2024Article
- Molecular states underlying neuronal cell type development and plasticity in the whisker cortex.bioRxiv : the preprint server for biology · 2024Article
- GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation.eLife · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Rapid plasticity of layer (L) 2/3 inhibitory circuits is an early step in sensory cortical map plasticity, but its cellular basis is unclear. We show that, in mice of either sex, 1 d whisker deprivation drives the rapid loss of L4-evoked feedforward inhibition and more modest loss of feedforward excitation in L2/3 pyramidal (PYR) cells, increasing the excitation-inhibition conductance ratio. Rapid disinhibition was due to reduced L4-evoked spiking by L2/3 parvalbumin (PV) interneurons, caused by reduced PV intrinsic excitability. This included elevated PV spike threshold, which is associated with an increase in low-threshold, voltage-activated delayed rectifier (presumed Kv1) and A-type potassium currents. Excitatory synaptic input and unitary inhibitory output of PV cells were unaffected. Functionally, the loss of feedforward inhibition and excitation was precisely coordinated in L2/3 PYR cells, so that peak feedforward synaptic depolarization remained stable. Thus, the rapid plasticity of PV intrinsic excitability offsets early weakening of excitatory circuits to homeostatically stabilize synaptic potentials in PYR cells of sensory cortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.