ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Distribution of Spinal Neuronal Networks Controlling Forward and Backward Locomotion.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Coordination dynamics and speed-related adaptations in forward and backward walking.Experimental brain research · 2026Article
- Functional Organization of the Spinal Locomotor Network Based on Analysis of Interneuronal Activity.The European journal of neuroscience · 2025Article
- Forward Stepping Evoked by Transvertebral Stimulation in the Decerebrate Cat.Neuromodulation : journal of the International Neuromodulation Society · 2024Article
- Functional mapping of the lower urinary tract by epidural electrical stimulation of the spinal cord in decerebrated cat model.Scientific reports · 2024Article
- Biomimetic computer-to-brain communication enhancing naturalistic touch sensations via peripheral nerve stimulation.Nature communications · 2024Article
- Closed-loop cervical epidural stimulation partially restores ipsilesional diaphragm EMG after acute CRespiratory physiology & neurobiology · 2024Article
- Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity.Cell reports · 2024Article
- Activation of the spinal and brainstem locomotor networks during free treadmill stepping in rats lacking dopamine transporter.Frontiers in molecular neuroscience · 2023Article
- Differences in backward and forward treadmill locomotion in decerebrated cats.The Journal of experimental biology · 2022Article
- Activity of Spinal Interneurons during Forward and Backward Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Simultaneous bidirectional hindlimb locomotion in decerebrate cats.Scientific reports · 2021Article
- The Spinal Control of Backward Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Rostrocaudal Distribution of the C-Fos-Immunopositive Spinal Network Defined by Muscle Activity during Locomotion.Brain sciences · 2021Article
- Comparison of operation of spinal locomotor networks activated by supraspinal commands and by epidural stimulation of the spinal cord in cats.The Journal of physiology · 2020Article
- Freezing of gait in Parkinson's disease may share the mechanisms of dystonia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Mapping of the Spinal Sensorimotor Network by Transvertebral and Transcutaneous Spinal Cord Stimulation.Frontiers in systems neuroscience · 2020Article
- Hindlimb motor responses evoked by microstimulation of the lumbar dorsal root ganglia during quiet standing.Journal of neural engineering · 2019Article
- Differential activation of lumbar and sacral motor pools during walking at different speeds and slopes.Journal of neurophysiology · 2019Article
- Nervous mechanisms of locomotion in different directions.Current opinion in physiology · 2019Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Higher vertebrates, including humans, are capable not only of forward (FW) locomotion but also of walking in other directions relative to the body axis [backward (BW), sideways, etc.]. Although the neural mechanisms responsible for controlling FW locomotion have been studied in considerable detail, the mechanisms controlling steps in other directions are mostly unknown. The aim of the present study was to investigate the distribution of spinal neuronal networks controlling FW and BW locomotion. First, we applied electrical epidural stimulation (ES) to different segments of the spinal cord from L2 to S2 to reveal zones triggering FW and BW locomotion in decerebrate cats of either sex. Second, to determine the location of spinal neurons activated during FW and BW locomotion, we used c-Fos immunostaining. We found that the neuronal networks responsible for FW locomotion were distributed broadly in the lumbosacral spinal cord and could be activated by ES of any segment from L3 to S2. By contrast, networks generating BW locomotion were activated by ES of a limited zone from the caudal part of L5 to the caudal part of L7. In the intermediate part of the gray matter within this zone, a significantly higher number of c-Fos-positive interneurons was revealed in BW-stepping cats compared with FW-stepping cats. We suggest that this region of the spinal cord contains the network that determines the BW direction of locomotion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.