ArticleStroke2018
Infections and Risk of Peripartum Stroke During Delivery Admissions.
Article in Stroke, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Global incidence and risk factors of pregnancy-related stroke: a systematic review and meta-analysis of over 270 million women.BMC pregnancy and childbirth · 2025Pooled it
- Pregnancy-associated stroke -a systematic review of subsequent pregnancies and maternal health.BMC pregnancy and childbirth · 2019Pooled it
- Stroke, infections, and New Mechanisms: a Narrative Review.Current neurology and neuroscience reports · 2025Review
- Article
- Stroke vs. Preeclampsia: Dangerous Liaisons of Hypertension and Pregnancy.Medicina (Kaunas, Lithuania) · 2023Review
- Stroke associated with Mycoplasma hominis infection: a case report.Journal of medical case reports · 2021Article
- Stroke in Pregnancy: A Multidisciplinary Approach.Obstetrics and gynecology clinics of North America · 2021Review
- Maternal Stroke: A Call for Action.Circulation · 2021Review
- Temporal Trends in Pregnancy-Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy.Journal of the American Heart Association · 2020Article
- Stroke in Pregnancy: A Focused Update.Anesthesia and analgesia · 2020Review
- Maternal Race/Ethnicity, Hypertension, and Risk for Stroke During Delivery Admission.Journal of the American Heart Association · 2020Observational
- Ischemic stroke and cerebral venous sinus thrombosis in pregnancy.Handbook of clinical neurology · 2020Review
- Infection During Delivery Hospitalization and Risk of Readmission for Postpartum Stroke.Stroke · 2019Article
- Maternal Stroke: an Update.Current atherosclerosis reports · 2019Review
- Age and Sex Are Critical Factors in Ischemic Stroke Pathology.Endocrinology · 2018Review
- Stroke Around Pregnancy; Protection and Prevention!Annals of Indian Academy of NeurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
background and purposePeripartum strokes during delivery admissions are rare but have high maternal morbidity. Infections have been proposed as a possible stroke trigger. We hypothesized that women who had infections diagnosed at the time of delivery admission would have higher risk of stroke during their delivery hospitalization.
methodsWe conducted a case-control study using state inpatient administrative databases for California (2007-2011), Florida (2009-2011), and New York (2009-2011). Women whose admission included a vaginal or cesarean delivery, with a new diagnosis of stroke during the admission, were considered cases and were randomly matched to 3 in-state controls by age/admission year and presence and severity of hypertensive disorders of pregnancy. The primary exposure of interest was infection of any type present on admission. Secondary exposures included race/ethnicity, payer status, delivery method, and known vascular risk factors such as chronic hypertension, diabetes mellitus, smoking, alcohol abuse, hypercoagulable states, coagulopathies, and renal disease. We used multivariable conditional logistic regression to estimate the odds ratios and 95% confidence intervals for the association of infections and known vascular risk factors with stroke risk.
resultsA total of 455 cases (mean age, 29.8), of whom 195 (42.9%) had hypertensive disorders of pregnancy, were matched with 1365 controls. Infection of any type present on admission increased the odds of stroke diagnosis during the admission (adjusted odds ratio, 1.74; 95% confidence interval, 1.29-2.35). Risk was higher for genitourinary infections (adjusted odds ratio, 2.56; 95% confidence interval, 1.25-5.24) and sepsis (adjusted odds ratio, 10.4; 95% confidence interval, 2.15-20.0). The association between infection and stroke during delivery admission did not differ by the presence of hypertensive disorders of pregnancy.
conclusionsInfections present on admission increased stroke risk during delivery admissions in women with and without hypertensive disorders of pregnancy. The results were driven by genitourinary infections and sepsis. Infections may be an underrecognized precipitant of peripartum stroke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.