ArticleDevelopment (Cambridge, England)2018
Feedback between tissue packing and neurogenesis in the zebrafish neural tube.
Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Progenitor neighborhoods function as transient niches to sustain olfactory neurogenesis.Stem cell reports · 2025Article
- Measuring and manipulating mechanical forces during development.Nature cell biology · 2025Review
- Notch pathway mutants do not equivalently perturb mouse embryonic retinal development.PLoS genetics · 2023Article
- Dopey2 and Pcdh7 orchestrate the development of embryonic neural stem cells/ progenitors in zebrafish.iScience · 2023Article
- Homemade: building the structure of the neurogenic niche.Frontiers in cell and developmental biology · 2023Review
- Regulation of size and scale in vertebrate spinal cord development.Wiley interdisciplinary reviews. Developmental biology · 2021Review
- Nuclear crowding and nonlinear diffusion during interkinetic nuclear migration in the zebrafish retina.eLife · 2020Article
- Simultaneous Requirements forThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Non-Cell-Autonomous Mechanisms in Radial Projection Neuron Migration in the Developing Cerebral Cortex.Frontiers in cell and developmental biology · 2020Review
- Pcgf1 Regulates Early Neural Tube Development Through Histone Methylation in Zebrafish.Frontiers in cell and developmental biology · 2020Article
- Interkinetic nuclear movements promote apical expansion in pseudostratified epithelia at the expense of apicobasal elongation.PLoS computational biology · 2019Article
- Polyacrylamide Bead Sensors for in vivo Quantification of Cell-Scale Stress in Zebrafish Development.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Balancing the rate of differentiation and proliferation in developing tissues is essential to produce organs of robust size and composition. Although many molecular regulators have been established, how these connect to physical and geometrical aspects of tissue architecture is poorly understood. Here, using high-resolution timelapse imaging, we find that changes to cell geometry associated with dense tissue packing play a significant role in regulating differentiation rate in the zebrafish neural tube. Specifically, progenitors that are displaced away from the apical surface due to crowding, tend to differentiate in a Notch-dependent manner. Using simulations we show that interplay between progenitor density, cell shape and changes in differentiation rate could naturally result in negative-feedback control on progenitor cell number. Given these results, we suggest a model whereby differentiation rate is regulated by density dependent effects on cell geometry to: (1) correct variability in cell number; and (2) balance the rates of proliferation and differentiation over development to 'fill' the available space.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.