Evidence map›Paper›PMID 29678809›Full record

ArticleBlood advances2018

Delayed immune reconstitution after allogeneic transplantation increases the risks of mortality and chronic GVHD.

Nelli Bejanyan, Claudio G Brunstein, Qing Cao, Aleksandr Lazaryan, Xianghua Luo, Julie Curtsinger, Rohtesh S Mehta, Erica Warlick, Sarah A Cooley, Bruce R Blazar and 4 more

Abstract read
In one paragraph

Article in Blood advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Randomized Double-Blind Phase II Trial of Fecal Microbiota Transplantation Versus Placebo in Allogeneic Hematopoietic Cell Transplantation and AML.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
    Trial
  2. Trial
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  4. Article
  5. Sarcopenia-associated CD8Annals of hematology · 2026
    Article
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  18. Article
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nelli BejanyanDivision of Hematology, Oncology and Transplantation.
Claudio G BrunsteinDivision of Hematology, Oncology and Transplantation.
Qing CaoBiostatistics Core, Masonic Cancer Center, and.
Aleksandr LazaryanDivision of Hematology, Oncology and Transplantation.
Xianghua LuoBiostatistics Core, Masonic Cancer Center, and.
Julie CurtsingerBlood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN.
Rohtesh S MehtaDivision of Hematology, Oncology and Transplantation.
Erica WarlickDivision of Hematology, Oncology and Transplantation.
Sarah A CooleyDivision of Hematology, Oncology and Transplantation.
Bruce R BlazarBlood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN.
Jeffrey S MillerDivision of Hematology, Oncology and Transplantation.
Daniel WeisdorfDivision of Hematology, Oncology and Transplantation.
John E WagnerBlood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN.
Michael R VernerisBlood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN.

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
Trial Design and Biostatistical Support CoreP01CA065493 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI J SUNIL RAO · 1995 to 2026
$48.2M
NCI NIH HHS P01 CA065493NCI NIH HHS P30 CA077598
6 · The paper itself

Abstract

Slow immune reconstitution is a major obstacle to the successful use of allogeneic hematopoietic cell transplantation (allo-HCT). As matched sibling donor (MSD) allo-HCT is regarded as the gold standard, we evaluated the pace of immune reconstitution in 157 adult recipients of reduced-intensity conditioning followed by MSD peripheral blood HCT (n = 68) and compared these to recipients of umbilical cord blood (UCB; n = 89). At day 28, UCB recipients had fewer natural killer (NK) cells than MSD recipients, but thereafter, NK cell numbers (and their subsets) were higher in UCB recipients. During the first 6 months to 1 year after transplant, UCB recipients had slower T-cell subset recovery, with lower numbers of CD3

Indexed as

Delayed Graft FunctionImmune ReconstitutionAdultAgedFemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansKiller Cells, NaturalMaleMiddle AgedMortalityRiskT-Lymphocyte SubsetsTransplantation, HomologousYoung Adult

Identifiers

PMID29678809
PMCPMC5916001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.