Evidence map›Paper›PMID 29678750›Full record

ArticleThe Journal of allergy and clinical immunology2018

Specific IgG

Alexander J Schuyler, Jeffrey M Wilson, Anubha Tripathi, Scott P Commins, Princess U Ogbogu, Patrice G Kruzsewski, Barrett H Barnes, Emily C McGowan, Lisa J Workman, Jonas Lidholm and 5 more

Abstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 96 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Circulating Food Allergen-Specific Antibodies, Beyond IgG4, Are Elevated in Eosinophilic Esophagitis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Type 2 immunity in allergic diseases.Cellular & molecular immunology · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Alexander J SchuylerDivision of Allergy & Clinical Immunology, University of Virginia, Charlottesville, Va.
Jeffrey M WilsonDivision of Allergy & Clinical Immunology, University of Virginia, Charlottesville, Va.
Anubha TripathiDivision of Allergy & Clinical Immunology, University of Virginia, Charlottesville, Va.
Scott P ComminsDivision of Rheumatology, Allergy & Immunology, University of North Carolina, Chapel Hill, NC.
Princess U OgboguAllergy and Immunology, Department of Otolaryngology, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Patrice G KruzsewskiDivision of Pediatric Gastroenterology, Hepatology & Nutrition, Emory University, Atlanta, Ga.
Barrett H BarnesDivision of Pediatric Gastroenterology, University of Virginia, Charlottesville, Va.
Emily C McGowanDivision of Allergy & Clinical Immunology, University of Virginia, Charlottesville, Va.
Lisa J WorkmanDivision of Allergy & Clinical Immunology, University of Virginia, Charlottesville, Va.
Jonas LidholmThermo Fisher Scientific, Uppsala, Sweden.
Sheryl L Rifas-ShimanDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, and Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
Emily OkenDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, and Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
Diane R GoldDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass.
Thomas A E Platts-MillsDivision of Allergy & Clinical Immunology, University of Virginia, Charlottesville, Va. Electronic address: tap2z@virginia.edu.
Elizabeth A ErwinCenter for Innovation in Pediatric Practice, Nationwide Children's Hospital, Columbus, Ohio. Electronic address: elizabeth.erwin@nationwidechildrens.org.
University of Virginia · USHarvard Pilgrim Health Care · USCenter for Innovation · USEmory University · USHarvard University · USThe Ohio State University Wexner Medical Center · USThermo Fisher Scientific (Sweden) · SEUniversity of North Carolina at Chapel Hill · US

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
IgE antibodies to the mammalian oligosaccharide galactose-alpha-1, 3-galactose (alpha-gal): immunology, epidemiology and relevance to allergic and inflammatory diseaseR37AI020565 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI THOMAS A. PLATTS-MILLS · 1992 to 2026
$8.4M
DUST MITE, COCKROACH AND CAT ALLERGENS IN HOUSES/ASTHMAR01AI020565 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PLATTS-MILLS, THOMAS A. · 1985 to 2017
$7.1M
The Fetal and Childhood Environment, Oxidative Balance, Inflammation and AsthmaR01AI102960 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLD, DIANE R, OKEN, EMILY · 2013 to 2017
$4.0M
Dietary Methyl Donors and Food Allergy Risk in the United StatesK23AI123596 · NIAID · UNIVERSITY OF VIRGINIA · PI MCGOWAN, EMILY CLARKE · 2017 to 2020
$767k
Change in allergen exposure and reversibility of the tolerant immune responseK23AI059317 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI ERWIN, ELIZABETH ANNE · 2008 to 2012
$524k
IgG4 and IgE antibodies to Cows Milk proteins in children with EosinophilicEsophagitisR21AI138227 · NIAID · UNIVERSITY OF VIRGINIA · PI PLATTS-MILLS, THOMAS A. · 2019 to 2020
$444k
NIAID NIH HHS K23 AI059317NIAID NIH HHS K23 AI123596NIAID NIH HHS R01 AI020565NIAID NIH HHS R01 AI102960NIAID NIH HHS R21 AI138227NIAID NIH HHS R37 AI020565NIAID NIH HHS T32 AI007496NICHD NIH HHS R01 HD034568
6 · The paper itself

Abstract

backgroundAllergen-specific IgG

objectiveWe sought to investigate serum food sIgG

methodsSera from 71 pediatric patients with EoE and 210 early adolescent children from an unselected birth cohort (Project Viva) were assayed for sIgG

resultsIn the EoE cohort high-titer sIgG

conclusionssIgG

Indexed as

AdolescentAllergensAnimalsChildChild, PreschoolEosinophilic EsophagitisFemaleHumansImmunoglobulin GMaleMilkAllergensImmunoglobulin Gchildrencow's milk proteinsEosinophilic esophagitisIgG(4) assaysmolecular allergens

Identifiers

PMID29678750
PMCPMC6245555
OpenAlexW2800209330

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.