Evidence map›Paper›PMID 29678640›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2018

Changes of glucose levels precede dementia in African-Americans with diabetes but not in Caucasians.

Hugh C Hendrie, Mengjie Zheng, Kathleen A Lane, Roberta Ambuehl, Christianna Purnell, Shanshan Li, Frederick W Unverzagt, Michael D Murray, Ashok Balasubramanyam, Chris M Callahan and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Hugh C HendrieIndiana University Center for Aging Research, Indianapolis, IN, USA; Regenstrief Institute, Inc., Indianapolis, IN, USA; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: hhendri@iupui.edu.
Mengjie ZhengDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
Kathleen A LaneDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
Roberta AmbuehlRegenstrief Institute, Inc., Indianapolis, IN, USA.
Christianna PurnellIndiana University Center for Aging Research, Indianapolis, IN, USA.
Shanshan LiDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
Frederick W UnverzagtDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Michael D MurrayRegenstrief Institute, Inc., Indianapolis, IN, USA; Purdue University College of Pharmacy, Indianapolis, IN, USA.
Ashok BalasubramanyamDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Chris M CallahanIndiana University Center for Aging Research, Indianapolis, IN, USA; Regenstrief Institute, Inc., Indianapolis, IN, USA; Department of Medicine, Indiana University School of Medicine, Houston, TX, USA.
Sujuan GaoDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicineBaylor College of Medicine · USRegenstrief Institute · USUniversity of Indianapolis · US

Funding

Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Longitudinal interactive vascular exposure and Alzheimer's DiseaseR01AG045350 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI GAO, SUJUAN · 2014 to 2016
$925k
NIA NIH HHS P30 AG010133NIA NIH HHS R01 AG045350
6 · The paper itself

Abstract

introductionChanges in glucose levels may represent a powerful metabolic indicator of dementia in African-Americans with diabetes. It is unclear whether these changes also occur in Caucasians.

methodsA secondary data analysis using electronic medical records from 5228 African-Americans and Caucasians aged ≥65 years was carried out. Mixed effects models with repeated serum glucose measurements were used to compare changes in glucose levels between African-Americans and Caucasian patients with and without incident dementia.

resultsAfrican-Americans and Caucasians with diabetes had significantly different changes in glucose levels by dementia status (P < .0001). African-Americans experienced a significant decline in glucose levels before the dementia diagnosis (estimated glucose decline 1.3421 mg/dL per year, P < .0001) than those who did not develop dementia. Caucasians with and without dementia showed stable glucose levels over time (P = .3071). DISCUSSION: Significant changes in glucose levels precede dementia in African-American patients with diabetes but not in Caucasians.

Indexed as

Black or African AmericanWhite PeopleAgedComorbidityDementiaDiabetes MellitusFemaleFollow-Up StudiesGlucoseHumansLongitudinal StudiesMaleMiddle AgedRisk FactorsGlucoseAfrican-AmericansAlzheimer's diseaseCaucasiansDementiaDiabetesEarly detectionElectronic medical recordsGlucose levelsLongitudinal risk factors

Identifiers

PMID29678640
PMCPMC6192866
OpenAlexW2800604971

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.