Evidence map›Paper›PMID 29678592›Full record

ArticleJournal of pharmaceutical sciences2018

Retina Compatible Interactions and Effective Modulation of Blood Ocular Barrier P-gp Activity by Third-Generation Inhibitors Improve the Ocular Penetration of Loperamide.

Karthik Yadav Janga, Akshaya Tatke, Surabhi Shukla, Surya P Lamichhane, Bharathi Avula, XiangDi Wang, Monica M Jablonski, Ikhlas A Khan, Soumyajit Majumdar

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Protein and polypeptide mediated delivery to the eye.Advanced drug delivery reviews · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Karthik Yadav JangaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Jackson, Mississippi 38677.
Akshaya TatkeDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Jackson, Mississippi 38677.
Surabhi ShuklaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Jackson, Mississippi 38677.
Surya P LamichhaneDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Jackson, Mississippi 38677.
Bharathi AvulaNational Center for Natural Products Research, The University of Mississippi, University, Mississippi 38655; Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, Mississippi 38677.
XiangDi WangDepartment of Ophthalmology, The University of Tennessee Health Science Center, Hamilton Eye Institute, Cordova, Tennessee 38018.
Monica M JablonskiDepartment of Ophthalmology, The University of Tennessee Health Science Center, Hamilton Eye Institute, Cordova, Tennessee 38018.
Ikhlas A KhanNational Center for Natural Products Research, The University of Mississippi, University, Mississippi 38655; Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, Mississippi 38677.
Soumyajit MajumdarDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Jackson, Mississippi 38677; Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, Mississippi 38677. Electronic address: majumso@olemiss.edu.
University of Mississippi · USUniversity of Tennessee Health Science Center · US

Funding

Evaluation and Inhibition of Efflux Pumps Expressed on the Blood Ocular BarrierR01EY022120 · NEI · UNIVERSITY OF MISSISSIPPI · PI MAJUMDAR, SOUMYAJIT · 2015 to 2018
$1.5M
NEI NIH HHS R01 EY022120
6 · The paper itself

Abstract

Effective drug delivery to the deeper ocular tissues remains an unresolved conundrum mainly due to the expression of multidrug resistance efflux proteins, besides tight junction proteins, in the blood ocular barriers (BOBs). Hence, the purpose of the current research was to investigate the ability of the third-generation efflux protein inhibitors, elacridar (EQ), and tariquidar (TQ), to diminish P-glycoprotein (P-gp) mediated efflux transport of loperamide (LOP), a P-gp substrate, across the BOB in Sprague Dawley rats. Initially, Western blot analysis confirmed the expression of P-gp in the iris-ciliary bodies and the retina choroid in the wild type rats. Next, the ocular distribution of LOP, in the presence and absence of EQ/TQ (at 2 doses), was evaluated. The significantly higher aqueous humor/plasma (D

Indexed as

AcridinesAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Biological TransportLoperamideMaleQuinolinesRats, Sprague-DawleyRetinaTetrahydroisoquinolinesAcridinesATP Binding Cassette Transporter, Subfamily B, Member 1ElacridarLoperamideQuinolinestariquidarTetrahydroisoquinolinesblood aqueous barrier (BAB)blood retinal barrier (BRB)elacridarelectroretinographyP-gp inhibitorstariquidar

Identifiers

PMID29678592
PMCPMC7339865
OpenAlexW2800311811

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.