ArticleInternational journal of radiation oncology, biology, physics2018
Long-Term Outcomes After Stereotactic Radiosurgery for Spine Metastases: Radiation Dose-Response for Late Toxicity.
Article in International journal of radiation oncology, biology, physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Cumulative dose, toxicity, and outcomes of spinal metastases re-irradiation : Systematic review on behalf of the Re-Irradiation Working Group of the Italian Association of Radiotherapy and Clinical Oncology (AIRO).Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021Pooled it
- Stereotactic body radiation therapy in elderly patients with spinal metastases.Journal of neuro-oncology · 2026Article
- Risk Factors for Vertebral Compression Fracture Following Spine Stereotactic Body Radiation Therapy.Advances in radiation oncology · 2026Article
- Stereotactic radiosurgery for lung cancer spinal metastases.Journal of neuro-oncology · 2025Article
- Long term outcomes following upfront stereotactic body radiotherapy alone for spinal metastases.Journal of neuro-oncology · 2025Article
- Risk Factors for Radiotherapy Failure in the Treatment of Spinal Metastases.Global spine journal · 2025Article
- Advanced Radiotherapy Technologies in Spine Tumors: What the Surgeon Needs to Know.Global spine journal · 2025Article
- Boron neutron capture therapy delays the decline in neurological function in a mouse model of metastatic spinal tumors.Cancer science · 2024Article
- The role of spine stereotactic radiosurgery for patients with breast cancer metastases.Journal of neuro-oncology · 2024Article
- Incidence and Prognostic Factors of Painful Vertebral Compression Fracture Caused by Spine Stereotactic Body Radiotherapy.Journal of clinical medicine · 2023Article
- Stereotactic body radiation therapy to the spine: contouring the cauda equina instead of the spinal cord is more practical as the organ at risk.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2023Article
- Evolution of surgical treatment of metastatic spine tumors.Journal of neuro-oncology · 2022Review
- Essential Concepts for the Management of Metastatic Spine Disease: What the Surgeon Should Know and Practice.Global spine journal · 2019Article
- Single-Fraction Radiotherapy (SFRT) For Bone Metastases: Patient Selection And Perspectives.Cancer management and research · 2019Review
- Selecting the Appropriate Radiation Therapy Technique for Malignant Spinal Cord Compression Syndrome.Frontiers in oncology · 2019Article
- Radiation recall myelitis following paclitaxel chemotherapy: The first reported case.Journal of radiosurgery and SBRT · 2018Article
- Conventional Radiotherapy and Stereotactic Radiosurgery in the Management of Metastatic Spine Disease.Technology in cancer research & treatmentReview
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo document the 5- and 10-year rates of late toxicity and vertebral compression fracture (VCF) in long-term survivors after stereotactic radiosurgery for spine metastases. METHODS AND MATERIALS: A retrospective review was performed on 562 patients treated with SRS for spine metastases between April 2001 and July 2011. Selecting those with at least 5-year survival after SRS, included were 43 patients who collectively underwent 84 treatments at 54 spine sites. Most were treated with single-fraction stereotactic radiosurgery to a median dose of 16 Gy (range, 12-24 Gy), and 56% of sites had received prior external beam radiation therapy. Late toxicities and VCFs occurring in the absence of tumor progression were recorded. Binary logistic regression was used to identify predictors of late complications.
resultsNine patients (17% of treatment sites) developed grade ≥2 late toxicities at a median time of 12.8 months (range, 4.2-59.0 months). Actuarial 5- and 10-year rates of grade ≥2 late toxicity were 17% and 17%, respectively. On multivariate analysis, only cumulative biologically effective dose (BED
conclusionStereotactic radiosurgery for primary treatment and reirradiation of spinal metastases is associated with a moderate risk of late toxicity with 10-year follow-up. Risk of late toxicity significantly increases with cumulative BED
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Registered trials
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