ArticleDiabetes & metabolism2019
Association between BMI and risk of severe hypoglycaemia in type 2 diabetes.
Article in Diabetes & metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Cardiac autonomic neuropathy modified the association between obesity and hypoglycemia in type 2 diabetes.Endocrine · 2024Trial
- Risk of Severe Hypoglycemia Associated With Concomitant Use of Sulfonylureas and Amiodarone.Diabetes, obesity & metabolism · 2026Article
- Heterogeneity of Treatment Effects Across Nine Glucose-Lowering Drug Classes in Type 2 Diabetes: Extension of the LEGEND-T2DM Network Study.Diabetes, obesity & metabolism · 2026Observational
- Heterogeneity of Treatment Effects Across Nine Glucose-Lowering Drug Classes in Type 2 Diabetes: Extension of the LEGEND-T2DM Network Study.medRxiv : the preprint server for health sciences · 2026Article
- Risk factors for hypoglycemia in hospitalized patients with diabetes: a retrospective analysis of electronic medical record data.Frontiers in pharmacology · 2026Article
- Article
- Comparison of logistic regression and artificial neural network models for predicting hypoglycemia in non-ICU inpatients with diabetes.BMC endocrine disorders · 2025Article
- Construction and validation of a hypoglycemia risk prediction model for hospitalized type 2 diabetes patients based on machine learning.BMC endocrine disorders · 2025Article
- Weight of time: exploring the link between obesity and aging.Aging clinical and experimental research · 2025Review
- Income and Severe Hypoglycemia in Type 2 Diabetes.JAMA network open · 2025Article
- Predicting hypoglycemia risk after gastrointestinal surgery in type 2 diabetes mellitus: a retrospective cohort study.Frontiers in endocrinology · 2025Article
- The Development of an Assessment Instrument for Behavior Toward Hypoglycemia Risk Among Type 2 Diabetes Mellitus Outpatients in Jakarta, Indonesia.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025Article
- Identification of factors associated with fear of hypoglycemia using the capability, opportunity, motivation and behavior model in people with type 2 diabetes mellitus: a cross-sectional study.Acta diabetologica · 2023Article
- Findings for iGlarLixi versus BIAsp 30 confirmed in groups of people with type 2 diabetes with different biomedical characteristics.Diabetes, obesity & metabolism · 2023Article
- Reactive hypoglycaemia during the OGTT after gestational diabetes mellitus: Metabolic implications and evolution.Diabetic medicine : a journal of the British Diabetic Association · 2022Article
- Analysis of Severe Hypoglycemia Among Adults With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease.JAMA network open · 2022Article
- The Impact of Hypoglycemia on Patients with Diabetes Mellitus: A Cross-Sectional Analysis.Journal of clinical medicine · 2022Article
- Hypoglycemia: Elucidating its circadian propensity and recovery time based on clinical parameters.Caspian journal of internal medicine · 2022Article
- Clinical Intervention Effect of a Predictive Model Constructed Based on Risk Factors for Falls in Elderly Patients during Hospitalization.Computational and mathematical methods in medicine · 2022Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
aimThis study aimed to assess the association between body mass index (BMI) and the development of severe hypoglycaemia in patients with type 2 diabetes (T2D), using nationwide data for the entire South Korean population.
methodsThe association between BMI and severe hypoglycaemia was retrospectively examined from claims and National Health examination data registered between 2002 and 2015. A total of 1,366,692 subjects assigned clinical codes for T2D and prescribed antihypoglycaemic agents were included. The primary outcome was an episode of severe hypoglycaemia after the baseline health examination.
resultsA total of 37,682 subjects (2.7%) experienced a new severe hypoglycaemic event during the follow-up period (mean: 8.6 years). An inverse J-shaped association was observed between BMI and severe hypoglycaemic events. The association between low BMI and high risk of severe hypoglycaemia was similar in subjects who had never smoked, did not consume alcohol, did not use insulin and had no major comorbidities, after adjusting for multiple confounding variables. This association was also found to be intensified in men, young people aged 30-49 years, those with major comorbidities and insulin users.
conclusionBMI and severe hypoglycaemia were found to be inversely associated. Thus, those who fall into the category of having low BMI and high risk of severe hypoglycaemia should be warned about the risk of having a hypoglycaemic event and be properly informed about hypoglycaemia to minimize the risk of fatal hypoglycaemia-related outcomes.
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Registered trials
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