ArticlePediatrics and neonatology2019
Phototherapy for neonatal hyperbilirubinemia and childhood eczema, rhinitis and wheeze.
Article in Pediatrics and neonatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01174875 (Developmental Pathways to Health and Disease), which is not on this map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Developmental Pathways to Health and Disease: Metabolic, Neurodevelopmental and Related Outcomes
Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Link Between History of Neonatal Jaundice and Early Childhood Allergic Diseases in South Korea.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Visual Acuity Thresholds in Preterm Newborns: An Experimental Study.Children (Basel, Switzerland) · 2024Article
- Hematological abnormality and associated factors in newborns with hyperbilirubinemia before and after phototherapy at University of Gondar Comprehensive Specialized Hospital.Scientific reports · 2024Article
- Probiotics' effects on gut microbiota in jaundiced neonates: a randomized controlled trial protocol.Frontiers in pediatrics · 2024Article
- Is neonatal phototherapy associated with a greater risk of childhood cancers?BMC pediatrics · 2022Article
- Challenges of phototherapy for neonatal hyperbilirubinemia (Review).Experimental and therapeutic medicine · 2021Review
- A systematic review and meta-analysis of risk factors associated with atopic dermatitis in Asia.The World Allergy Organization journal · 2020Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe pathogenesis of allergic diseases in childhood may be attributed to influences of early environmental stimuli on fetal and neonatal immune regulation. Neonatal hyperbilirubinemia is common in the Asian population and up to 20% of infants require phototherapy. We examined the hypothesis that phototherapy for neonatal hyperbilirubinemia modulates the infant's risk of developing eczema, rhinitis and wheeze in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort.
methodInterviewers collected information on demographics, lifestyle, birth data and allergic outcomes. Atopic sensitization was assessed through skin prick testing (SPT) to aeroallergens and food allergens.
resultsA total of 135 (12.8%) children underwent phototherapy for neonatal hyperbilirubinemia. Infants who underwent phototherapy were of a significantly lower mean (SD) gestational age [37.5 (2.5) weeks] compared to those who did not [38.5 (1.2) weeks p < 0.01]. A higher proportion of infants born by Caesarean section underwent phototherapy compared to those who were born vaginally (17.5% vs 10.7%, p < 0.01). There were no differences in prevalence of allergen sensitization, eczema, rhinitis and early onset wheeze with use of nebulizer in the first 5 years of life between subjects that underwent phototherapy and those that did not. There were also no associations between mean bilirubin peak levels within the phototherapy group with development of eczema, rhinitis and early onset wheeze in the first 5 years of life.
conclusionWe found no evidence for a link between phototherapy for neonatal hyperbilirubinemia and childhood allergic outcomes in this prospective mother-offspring cohort.
trial registrationNCT01174875 Registered 1 July 2010, retrospectively registered.
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