ReviewSleep medicine reviews2018
Altered ultradian cortisol rhythmicity as a potential neurobiologic substrate for chronic insomnia.
Review in Sleep medicine reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 82 citations in OpenAlex.
- Glucocorticoid ultradian rhythmicity differentially regulates mood and resting state networks in the human brain: A randomised controlled clinical trial.Psychoneuroendocrinology · 2021Trial
- Causal relationships between insomnia and blood metabolome: a Mendelian randomization study with mouse experimental validation.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Sleep disturbances are associated with greater healthcare utilization in children with autism spectrum disorder.Journal of neurodevelopmental disorders · 2024Article
- Advancements in Cortisol Detection: From Conventional Methods to Next-Generation Technologies for Enhanced Hormone Monitoring.ACS sensors · 2024Review
- Correlation between symptoms and cognitive function changes in patients with primary insomnia and pathways in gut microbiota.Biochemistry and biophysics reports · 2024Article
- Increased Resting-State Functional Connectivity in Patients With Autoimmune Addison Disease.The Journal of clinical endocrinology and metabolism · 2024Article
- Salivary Brain-Derived Neurotrophic Factor and Cortisol Associated with Psychological Alterations in University Students.Diagnostics (Basel, Switzerland) · 2024Article
- Conceptualizing the Biopsychosocial-Spiritual Health Influences of Adverse Childhood Experiences and the Application of Primary Care Behavioral Health for Their Treatment.Journal of religion and health · 2024Review
- Bidirectional mechanism of comorbidity of depression and insomnia based on synaptic plasticity.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Evaluation of the correlation between sleep quality and work engagement among nurses in Shanghai during the post-epidemic era.Nursing open · 2023Article
- Brain structure in autoimmune Addison's disease.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Effects of schedule exercise therapy on chronic insomnia.Medicine · 2022Article
- Associations between burnout symptoms and sleep among workers during the COVID-19 pandemic.Sleep medicine · 2022Article
- Changes in telomere length and serum neurofilament light chain levels in female patients with chronic insomnia disorder.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Effects of electrostatic therapy on nighttime sleep and daytime symptoms in patients with chronic insomnia: Evidences from an open label study.Frontiers in neuroscience · 2022Article
- Sleep Quality Partially Mediate the Relationship Between Depressive Symptoms and Cognitive Function in Older Chinese: A Longitudinal Study Across 10 Years.Psychology research and behavior management · 2022Article
- Insomnia with physiological hyperarousal is associated with lower weight: a novel finding and its clinical implications.Translational psychiatry · 2021Article
- Insomnia and depression: clinical associations and possible mechanistic links.Current opinion in psychology · 2020Review
- Sleep and Wellbeing, Now and in the Future.International journal of environmental research and public health · 2020Article
- Acute and Chronic Insomnia: What Has Time and/or Hyperarousal Got to Do with It?Brain sciences · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Chronic insomnia is highly prevalent and associated with significant morbidity (i.e., confers risk for multiple psychiatric and medical disorders, such as depression and hypertension). Therefore, it is essential to identify factors that perpetuate this disorder. One candidate factor in the neurobiology of chronic insomnia is hypothalamic-pituitary-adrenal-axis dysregulation, and in particular, alterations in circadian cortisol rhythmicity. Cortisol secretory patterns, however, fluctuate with both a circadian and an ultradian rhythm (i.e., pulses every 60-120 min). Ultradian cortisol pulses are thought to be involved in the maintenance of wakefulness during the day and their relative absence at night may allow for the consolidation of sleep and/or shorter nocturnal awakenings. It is possible that the wakefulness that occurs in chronic insomnia may be associated with the aberrant occurrence of cortisol pulses at night. While cortisol pulses naturally occur with transient awakenings, it may also be the case that cortisol pulsatility becomes a conditioned phenomenon that predisposes one to awaken and/or experience prolonged nocturnal awakenings. The current review summarizes the literature on cortisol rhythmicity in subjects with chronic insomnia, and proffers the suggestion that it may be abnormalities in the ultradian rather than circadian cortisol that is associated with the pathophysiology of insomnia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.