Evidence map›Paper›PMID 29678370›Full record

Trial reportClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2018

The response of the central and peripheral tremor component to octanoic acid in patients with essential tremor.

Hongmei Cao, Johanna Thompson-Westra, Mark Hallett, Dietrich Haubenberger

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Essential tremor: Clinical perspectives and pathophysiology.Journal of the neurological sciences · 2022
    Review
  6. Rationale and Evidence for Peripheral Nerve Stimulation for Treating Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2022
    Review
  7. Tracking the central and peripheral origin of tremor.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Hongmei CaoDepartment of Neurology, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, 277 Yanta Western Road, Xi'an 710061, China; National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA.
Johanna Thompson-WestraNational Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA.
Mark HallettNational Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA.
Dietrich HaubenbergerNational Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA. Electronic address: dietrich.haubenberger@nih.gov.
National Institutes of Health · US

Funding

Pathophysiology of Involuntary Movements and Volitional DisordersZIANS002667 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI HALLETT, MARK · 2009 to 2023
$17.7M
PHYSIOLOGICAL ANALYSIS OF INVOLUNTARY MOVEMENTSZ01NS002667 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI HALLETT, MARK A · 1985 to 2008
$2.2M
Intramural NIH HHS Z01 NS002667
6 · The paper itself

Abstract

objectiveTo investigate the effect of octanoic acid (OA) on the peripheral component of tremor, as well as OA's differential effects on the central and peripheral tremor component in essential tremor (ET) patients.

methodsWe analyzed postural tremor accelerometry data from a double-blind placebo-controlled cross-over study evaluating the effect of 4 mg/kg OA in ET. The weighted condition was used to identify tremor power for both the central and peripheral tremor components. Exploratory non-parametric statistical analyses were used to describe the relation between the central and peripheral component of tremor power.

resultsA peripheral tremor component was identified in 4 out of 18 subjects. Tremor power was reduced after OA administration in both the central and the peripheral tremor component. There was a positive correlation of tremor power between the central and peripheral component, both after placebo and OA.

conclusionsWhen present, the peripheral component was closely related to the central tremor component. We hypothesize that the magnitude of the peripheral mechanical component of tremor is determined by that of the central component. SIGNIFICANCE: Both central and peripheral component of tremor are reduced after OA, with the central component providing the energy driving the peripheral component.

Indexed as

AdultCaprylatesCross-Over StudiesDouble-Blind MethodElectromyographyEssential TremorFemaleHumansMaleTreatment OutcomeCaprylatesoctanoic acidElectromyographyEssential tremorOctanoic acidPhysiological tremor

Identifiers

PMID29678370
PMCPMC6530908
OpenAlexW2796272546

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.