Evidence map›Paper›PMID 29678336›Full record

ArticleThe American journal of cardiology2018

Stress Myocardial Blood Flow Heterogeneity Is a Positron Emission Tomography Biomarker of Ventricular Arrhythmias in Patients With Hypertrophic Cardiomyopathy.

Dai-Yin Lu, Hulya Yalçin, Fatih Yalçin, Min Zhao, Sanjay Sivalokanathan, Ines Valenta, Abdel Tahari, Martin G Pomper, Theodore P Abraham, Thomas H Schindler and 1 more

Open access · greenAbstract read
In one paragraph

Article in The American journal of cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. 2-[Scientific reports · 2025
    Article
  5. Review
  6. Review
  7. Patient selection, ventricular tachycardia substrate delineation, and data transfer for stereotactic arrhythmia radioablation: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology and the Heart Rhythm Society.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Mechanisms and prognostic impact of myocardial ischaemia in hypertrophic cardiomyopathy.The international journal of cardiovascular imaging · 2023
    Review
  12. Role of nuclear cardiology in diagnosis and risk stratification of coronary microvascular disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Relative disagreement among different software packages in PET-flow quantitation: An appeal for consistency.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  19. Review
  20. Adding clinical value with coronary flow assessment in hypertrophic obstructive cardiomyopathy.International journal of cardiology. Heart & vasculature · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Dai-Yin LuHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, Maryland; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Public Health, National Yang-Ming University, Taipei, Taiwan.
Hulya YalçinHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, Maryland.
Fatih YalçinHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, Maryland.
Min ZhaoRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland.
Sanjay SivalokanathanHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, Maryland.
Ines ValentaRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland.
Abdel TahariRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland.
Martin G PomperRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland.
Theodore P AbrahamHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, Maryland; Hypertrophic Cardiomyopathy Center, Division of Cardiology, University of California San Francisco, San Francisco, California.
Thomas H SchindlerRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland.
M Roselle AbrahamHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, Maryland; Hypertrophic Cardiomyopathy Center, Division of Cardiology, University of California San Francisco, San Francisco, California. Electronic address: Roselle.Abraham@ucsf.edu.
Johns Hopkins University · USNational Yang Ming Chiao Tung University · TW

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Imaging of the Myocardial Microenvironment to Facilitate Stem Cell EngraftmentR01HL092985 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ABRAHAM, MARIA ROSELLE, WAHL, RICHARD LEO · 2010 to 2014
$2.3M
NCI NIH HHS P30 CA006973NHLBI NIH HHS R01 HL092985
6 · The paper itself

Abstract

Patients with hypertrophic cardiomyopathy (HC) are at increased risk of sudden cardiac death. Abnormalities in myocardial blood flow (MBF) detected by positron emission tomography (PET) are common in HC, but a PET marker that identifies patients at risk of sudden cardiac death is lacking. We hypothesized that disparities in regional myocardial perfusion detected by PET would identify patients with HC at risk of ventricular arrhythmias. To test this hypothesis, we quantified global and regional MBFs by

Indexed as

RegistriesAcademic Medical CentersAdultAgedBaltimoreBiomarkersCardiomyopathy, HypertrophicCohort StudiesDeath, Sudden, CardiacDisease ProgressionFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial Perfusion ImagingBiomarkers

Identifiers

PMID29678336
PMCPMC5966031
OpenAlexW2792961102

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.