ArticleUltrasound in medicine & biology2018
Measurement of Wall Shear Stress Exerted by Flowing Blood in the Human Carotid Artery: Ultrasound Doppler Velocimetry and Echo Particle Image Velocimetry.
Article in Ultrasound in medicine & biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Haemodynamic and biomechanical biomarker analysis of carotid fibromuscular dysplasia via fluid-structure interaction.Biomechanics and modeling in mechanobiology · 2026Article
- Artificial Intelligence Across the Echocardiographic Workflow: A Narrative Review for Clinicians.Cureus · 2026Review
- Mechanomedicine in digestive surgery: a theranostic framework integrating mechanical diagnostics and therapeutic modulation across the perioperative continuum.Theranostics · 2026Review
- Three-dimensional modeling of flow through microvascular beds and surrounding interstitial spaces.Bioengineering & translational medicine · 2026Article
- A Pseudo-Spectral Method for Wall Shear Stress Estimation from Doppler Ultrasound Imaging in Coronary Arteries.Cardiovascular engineering and technology · 2024Review
- Hemodynamics in Doppler ultrasonography.Ultrasonography (Seoul, Korea) · 2024Article
- Development of an in vitro setup for flow studies in a stented carotid artery bifurcation.Medical & biological engineering & computing · 2024Article
- Effects of accumulated exercise on the stiffness and hemodynamics of the common carotid artery.Frontiers in physiology · 2024Article
- Wall shear stress: the challenges of a rising imaging marker in current clinical practice.Journal of thoracic disease · 2023Article
- Adaptive Wall Shear Stress Imaging in Phantoms, Simulations and In Vivo.IEEE transactions on bio-medical engineering · 2023Article
- Contrast Agent-Free Assessment of Blood Flow and Wall Shear Stress in the Rabbit Aorta using Ultrasound Image Velocimetry.Ultrasound in medicine & biology · 2022Article
- Differences in Blood Flow Patterns and Endothelial Shear Stress at the Carotid Artery Using Different Exercise Modalities and Intensities.Frontiers in physiology · 2022Article
- The association of peak systolic velocity in the carotid artery with coronary heart disease: A study based on portable ultrasound.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2021Article
- Manual and Automatic Image Analysis Segmentation Methods for Blood Flow Studies in Microchannels.Micromachines · 2021Review
- Article
- The Rheology of the Carotid Sinus: A Path Toward Bioinspired Intervention.Frontiers in bioengineering and biotechnology · 2021Review
- Determining Haemodynamic Wall Shear Stress in the Rabbit Aorta In Vivo Using Contrast-Enhanced Ultrasound Image Velocimetry.Annals of biomedical engineering · 2020Article
- Acute Effects of Different Intensities of Cycling Acute Exercise on Carotid Arterial Apparent Elasticity and Hemodynamic Variables.BioMed research international · 2020Article
- Measurement in opaque flows: a review of measurement techniques for dispersed multiphase flows.Acta mechanica · 2020Review
- Biomechanical Forces and Atherosclerosis: From Mechanism to Diagnosis and Treatment.Current cardiology reviews · 2020Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Vascular endothelial cells lining the arteries are sensitive to wall shear stress (WSS) exerted by flowing blood. An important component of the pathophysiology of vascular diseases, WSS is commonly estimated by centerline ultrasound Doppler velocimetry (UDV). However, the accuracy of this method is uncertain. We have previously validated the use of a novel, ultrasound-based, particle image velocimetry technique (echo PIV) to compute 2-D velocity vector fields, which can easily be converted into WSS data. We compared WSS data derived from UDV and echo PIV in the common carotid artery of 27 healthy participants. Compared with echo PIV, time-averaged WSS was lower using UDV (28 ± 35%). Echo PIV revealed that this was due to considerable spatiotemporal variation in the flow velocity profile, contrary to the assumption that flow is steady and the velocity profile is parabolic throughout the cardiac cycle. The largest WSS underestimation by UDV was found during peak systole (118 ± 16%) and the smallest during mid-diastole (4.3± 46%). The UDV method underestimated WSS for the accelerating and decelerating systolic measurements (68 ± 30% and 24 ± 51%), whereas WSS was overestimated for end-diastolic measurements (-44 ± 55%). Our data indicate that UDV estimates of WSS provided limited and largely inaccurate information about WSS and that the complex spatiotemporal flow patterns do not fit well with traditional assumptions about blood flow in arteries. Echo PIV-derived WSS provides detailed information about this important but poorly understood stimulus that influences vascular endothelial pathophysiology.
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