Evidence map›Paper›PMID 29678195›Full record

ArticleTrials2018

Does sensorimotor upper limb therapy post stroke alter behavior and brain connectivity differently compared to motor therapy? Protocol of a phase II randomized controlled trial.

Nele De Bruyn, Bea Essers, Liselot Thijs, Annick Van Gils, Lisa Tedesco Triccas, Sarah Meyer, Kaat Alaerts, Geert Verheyden

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03236376 (Behavioral and Brain Connectivity Analysis of Upper Limb Sensorimotor Rehabilitation Post Stroke), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03236376 nacompletednot on this map

Behavioral and Brain Connectivity Analysis of Upper Limb Sensorimotor Rehabilitation Post Stroke: a Randomized Controlled Trial

TypeinterventionalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2017 to 2020Enrolled59ConditionsStrokeArmsadditional sensorimotor therapy for the upper limb, additional motor therapy for the upper limb after stroke
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Interventions for perceptual disorders following stroke.The Cochrane database of systematic reviews · 2022
    Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nele De BruynKU Leuven - University of Leuven, Department of Rehabilitation Sciences, Tervuursevest 101, box 1501, 3001, Leuven, Belgium. nele.debruyn@kuleuven.be.ORCID http://orcid.org/0000-0002-8011-1303
Bea EssersKU Leuven - University of Leuven, Department of Rehabilitation Sciences, Tervuursevest 101, box 1501, 3001, Leuven, Belgium.
Liselot ThijsKU Leuven - University of Leuven, Department of Rehabilitation Sciences, Tervuursevest 101, box 1501, 3001, Leuven, Belgium.
Annick Van GilsKU Leuven - University of Leuven, Department of Rehabilitation Sciences, Tervuursevest 101, box 1501, 3001, Leuven, Belgium.
Lisa Tedesco TriccasKU Leuven - University of Leuven, Department of Rehabilitation Sciences, Tervuursevest 101, box 1501, 3001, Leuven, Belgium.
Sarah MeyerKU Leuven - University of Leuven, Department of Rehabilitation Sciences, Tervuursevest 101, box 1501, 3001, Leuven, Belgium.
Kaat AlaertsKU Leuven - University of Leuven, Department of Rehabilitation Sciences, Tervuursevest 101, box 1501, 3001, Leuven, Belgium.
Geert VerheydenKU Leuven - University of Leuven, Department of Rehabilitation Sciences, Tervuursevest 101, box 1501, 3001, Leuven, Belgium.

Funding

Fonds Wetenschappelijk Onderzoek 1189817N
6 · The paper itself

Abstract

backgroundThe role of somatosensory feedback in motor performance has been warranted in the literature. Although sensorimotor deficits are common after stroke, current rehabilitation approaches primarily focus on restoring upper limb motor ability. Evidence for integrative sensorimotor rehabilitation approaches is scarce, as is knowledge about neural correlates of somatosensory impairments after stroke and the effect of rehabilitation on brain connectivity level. Therefore, we aim to investigate changes in sensorimotor function and brain connectivity following a sensorimotor therapy program compared to an attention-matched motor therapy program for the upper limb after stroke.

methodsAn assessor-blinded randomized controlled trial will be conducted. Sixty inpatient rehabilitation patients up to eight weeks after stroke will be included. Patients will be randomized to either an experimental group receiving sensorimotor therapy or a control group receiving attention-matched motor therapy for the upper limb, with both groups receiving conventional therapy. Thus, all patients will receive extra therapy, a total of 16 1-h sessions over four weeks. Patients will be assessed at baseline, after four weeks of training, and after four weeks of follow-up. Primary outcome measure is the Action Research Arm Test. Secondary outcome measures will consist of somatosensory, motor and cognitive assessments, and a standardized resting-state functional magnetic resonance imaging protocol. DISCUSSION: The integration of sensory and motor rehabilitation into one therapy model might provide the added value of this therapy to improve sensorimotor performance post stroke. Insight in the behavioral and brain connectivity changes post therapy will lead to a better understanding of working mechanisms of therapy and will provide new knowledge for patient-tailored therapy approaches.

trial registrationClinicalTrials.gov, NCT03236376 . Registered on 8 August 2017.

Indexed as

Feedback, SensoryMotor ActivitySensory ThresholdsBelgiumClinical Trials, Phase II as TopicHumansNeural PathwaysRandomized Controlled Trials as TopicRecovery of FunctionSensorimotor CortexStrokeStroke RehabilitationTime FactorsTreatment OutcomeUpper ExtremityFunctional connectivityRandomized controlled trialSensorimotor functionStrokeUpper limb

Identifiers

PMID29678195
PMCPMC5910616

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.