S Marks the Spot: Linking the Antioxidant Activity of N-Acetyl Cysteine to H

Matthew M Cerda, Michael D Pluth

Abstract readComment

In one paragraph

Article in Cell chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

Intersection of HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
Review
Hydrogen sulfide as a new therapeutic target of pulmonary hypertension: an overview with update on immunomodulation.Frontiers in pharmacology · 2025
Review
Using resonance synchronous spectroscopy to characterize the reactivity and electrophilicity of biologically relevant sulfane sulfur.Redox biology · 2019
Article
Potential for Heightened Sulfur-Metabolic Capacity in Coastal Subtropical Microalgae.iScience · 2019
Article
Hydrogen Sulfide (HFrontiers in pharmacology · 2018
Review

4 · The record

Corrections and comments

Comment on
N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2018

5 · Who and what money

Authors and funding

2 authors.

Matthew M CerdaDepartment of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA; Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA; Materials Science Institute, University of Oregon, Eugene, OR 97403, USA.

Michael D PluthDepartment of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA; Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA; Materials Science Institute, University of Oregon, Eugene, OR 97403, USA. Electronic address: pluth@uoregon.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N-Acetyl cysteine (NAC) is commonly used as an antioxidant and cytoprotectant, yet a broadly applicable mechanism of these activities has remained elusive. In this issue of Cell Chemical Biology, Ezeriņa et al. (2018) report an alternative mechanism for NAC cytoprotection and antioxidant activity by demonstrating that NAC treatment increases sulfane sulfur production via intermediate H

Indexed as

AcetylcysteineAntioxidantsCysteineSulfurAcetylcysteineAntioxidantsCysteineSulfur

Identifiers

PMID29677486

DOI10.1016/j.chembiol.2018.04.001

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.