ArticleAmerican journal of physiology. Heart and circulatory physiology2018
Ondansetron blocks wild-type and p.F503L variant small-conductance Ca
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In one paragraph
Article in American journal of physiology. Heart and circulatory physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Pharmacogenomic markers associated with drug-induced QT prolongation: a systematic review.PharmacogenomicsPooled it
- Promethazine use and QT prolongation risk during treatment with a shortened all-oral regimen for MDR/RR-TB.JAC-antimicrobial resistance · 2026Article
- Antiarrhythmic effects of mirabegron on ventricular fibrillation in Langendorff-perfused rabbit ventricles.The Journal of physiology · 2025Article
- Small-conductance calcium-activated potassium channels in the heart: expression, regulation and pathological implications.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Activation of small conductance CaThe Journal of physiology · 2023Article
- Stop the beat to see the rhythm: excitation-contraction uncoupling in cardiac research.American journal of physiology. Heart and circulatory physiology · 2021Review
- The regulation of the small-conductance calcium-activated potassium current and the mechanisms of sex dimorphism in J wave syndrome.Pflugers Archiv : European journal of physiology · 2021Review
- Inhibition of Small-Conductance, CaFrontiers in pharmacology · 2021Article
- Sex-specific IHeart rhythm · 2021Article
- Article
- Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation.The Journal of general physiology · 2020Article
- Drug-specific risk of severe QT prolongation following acute drug overdose.Clinical toxicology (Philadelphia, Pa.) · 2020Article
- The Small Conductance Calcium-Activated Potassium Channel Inhibitors NS8593 and UCL1684 Prevent the Development of Atrial Fibrillation Through Atrial-Selective Inhibition of Sodium Channel Activity.Journal of cardiovascular pharmacology · 2020Article
- Effects of ondansetron on apamin-sensitive small conductance calcium-activated potassium currents in pacing-induced failing rabbit hearts.Heart rhythm · 2020Article
- Small-conductance calcium-activated potassium current modulates the ventricular escape rhythm in normal rabbit hearts.Heart rhythm · 2019Article
- The KFrontiers in pharmacology · 2019Article
- Concomitant SK current activation and sodium current inhibition cause J wave syndrome.JCI insight · 2018Article
- Sex-specific activation of SK current by isoproterenol facilitates action potential triangulation and arrhythmogenesis in rabbit ventricles.The Journal of physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 5 institutions in 3 countries.
Jum-Suk KoThe Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana.
Shuai GuoThe Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana.
Jonathan HasselThe Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana.
Patricia Celestino-SoperDepartment of Medical and Molecular Genetics, Indiana University School of Medicine , Indianapolis, Indiana.
Ty C LynnesDepartment of Medical and Molecular Genetics, Indiana University School of Medicine , Indianapolis, Indiana.
James E TisdaleDepartment of Pharmacy Practice, College of Pharmacy, Purdue University , West Lafayette, Indiana.
James J ZhengRegenstrief Institute , Indianapolis, Indiana.
Stanley E TaylorDepartment of Biostatistics, Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana.
Tatiana ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine , Indianapolis, Indiana.
Michael D MurrayDepartment of Pharmacy Practice, College of Pharmacy, Purdue University , West Lafayette, Indiana.
Richard J KovacsThe Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana.
Xiaochun LiDepartment of Biostatistics, Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana.
Shien-Fong LinThe Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana.
Zhenhui ChenThe Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana.
Matteo VattaThe Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana.
Peng-Sheng ChenThe Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana.
Michael RubartDepartment of Pediatrics, Riley Heart Research Center, Indiana University School of Medicine , Indianapolis, Indiana.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicinePurdue University West Lafayette · USNational Yang Ming Chiao Tung University · TWRegenstrief Institute · US
Funding
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3MSK Current, beta-3 adrenoceptor activation and Sex Differences in Ventricular ArrhythmogenesisR01HL139829 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI PENG-SHENG CHEN, ZHILIN QU · 2018 to 2026
$4.5MNCATS NIH HHS UL1 TR001108NHLBI NIH HHS R01 HL139829
Abstract
Apamin-sensitive small-conductance Ca
Indexed as
AnimalsAnti-Arrhythmia AgentsCalciumCells, CulturedFemaleHEK293 CellsHumansLong QT SyndromeMiceMice, Inbred C57BLMiddle AgedMutation, MissenseOndansetronPotassium Channel BlockersSmall-Conductance Calcium-Activated Potassium ChannelsAnti-Arrhythmia AgentsCalciumOndansetronPotassium Channel BlockersSmall-Conductance Calcium-Activated Potassium ChannelsCa2+-activated K+ channel subfamily N variantsdrug-induced long QT syndromeondansetronsmall-conductance Ca2+-activated K+ channel
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.