ArticlePLoS neglected tropical diseases2018
A 2015 outbreak of flea-borne rickettsiosis in San Gabriel Valley, Los Angeles County, California.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Organ Donor Transmission of Rickettsia typhi to Kidney Transplant Recipients, Texas, USA, 2024.Emerging infectious diseases · 2025Article
- Survey of Fleas and Ticks for Rickettsia rickettsii and Rickettsia typhi in the El Paso Community and Other Areas in Texas, New Mexico, and Ciudad Juarez, Mexico.The American journal of tropical medicine and hygiene · 2025Article
- Oral Flea Preventive to Control Rickettsia typhi-Infected Fleas on Reservoir Opossums, Galveston, Texas, USA, 2023-2024.Emerging infectious diseases · 2025Article
- Cat Flea Coinfection withVector borne and zoonotic diseases (Larchmont, N.Y.) · 2024Article
- Surveillance of Flea-Borne Typhus in California, 2011-2019.The American journal of tropical medicine and hygiene · 2024Article
- Murine Typhus: A Review of a Reemerging Flea-Borne Rickettsiosis with Potential for Neurologic Manifestations and Sequalae.Infectious disease reports · 2023Review
- Vector-Borne Disease in Wild Mammals Impacted by Urban Expansion and Climate Change.EcoHealth · 2023Article
- Current Data onMicroorganisms · 2022Article
- Rickettsial infections: A blind spot in our view of neglected tropical diseases.PLoS neglected tropical diseases · 2021Article
- Manifestations and Management of Flea-Borne Rickettsioses.Research and reports in tropical medicine · 2021Review
- History, Rats, Fleas, and Opossums. II. The Decline and Resurgence of Flea-Borne Typhus in the United States, 1945-2019.Tropical medicine and infectious disease · 2020Review
- Rickettsiae Within the Fleas of Feral Cats in Galveston, Texas.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Although flea-borne rickettsiosis is endemic in Los Angeles County, outbreaks are rare. In the spring of 2015 three human cases of flea-borne rickettsiosis among residents of a mobile home community (MHC) prompted an investigation. Fleas were ubiquitous in common areas due to presence of flea-infested opossums and overabundant outdoor cats and dogs. The MHC was summarily abated in June 2015, and within five months, flea control and removal of animals significantly reduced the flea population. Two additional epidemiologically-linked human cases of flea-borne rickettsiosis detected at the MHC were suspected to have occurred before control efforts began. Molecular testing of 106 individual and 85 pooled cat fleas, blood and ear tissue samples from three opossums and thirteen feral cats using PCR amplification and DNA sequencing detected rickettsial DNA in 18.8% of the fleas. Seventeen percent of these cat fleas tested positive for R. felis-specific DNA compared to under two (<2) percent for Candidatus R. senegalensis-specific DNA. In addition, serological testing of 13 cats using a group-specific IgG-ELISA detected antibodies against typhus group rickettsiae and spotted fever group rickettsiae in six (46.2%) and one (7.7%) cat, respectively. These results indicate that cats and their fleas may have played an active role in the epidemiology of the typhus group and/or spotted fever group rickettsial disease(s) in this outbreak.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.