ArticlePloS one2018
Sweat glucose and GLUT2 expression in atopic dermatitis: Implication for clinical manifestation and treatment.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Pooled it
- Glycemic Instability and Skin Health: Metabolic Mechanisms Linking Dietary Patterns with Cutaneous Dysfunction.Journal of clinical medicine · 2026Review
- Sweat glands in action: the role of biological and environmental factors, exercise, and dermatologic conditions in sudomotor function.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026Review
- Sweat as a diagnostic biofluid: analytical advances and future directions.Journal of pharmaceutical analysis · 2026Review
- Sweat components as a promising monitoring tool for systemic diseases.The journal of physiological sciences : JPS · 2026Review
- Insulin Resistance, Metabolic Syndrome, and Inflammatory Skin Disease.Journal of clinical medicine · 2026Review
- Skin sensing and wearable technology as tools to measure atopic dermatitis severity.Skin health and disease · 2024Review
- Wearable Sensors for Physiological Condition and Activity Monitoring.Small science · 2024Article
- Differential patterns of sweat and blood lactate concentration response during incremental exercise in varied ambient temperatures: A pilot study.Temperature (Austin, Tex.) · 2024Article
- Examining the Genetic Role of rs8192675 Variant in Saudi Women Diagnosed with Polycystic Ovary Syndrome.Diagnostics (Basel, Switzerland) · 2023Article
- Diseases from the Spectrum of Dermatitis and Eczema: Can "Omics" Sciences Help with Better Systematics and More Accurate Differential Diagnosis?International journal of molecular sciences · 2023Review
- Skin Microbiome, Metabolome and Skin Phenome, from the Perspectives of Skin as an Ecosystem.Phenomics (Cham, Switzerland) · 2022Review
- An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study.International journal of molecular sciences · 2022Review
- Can Wearable Sweat Lactate Sensors Contribute to Sports Physiology?ACS sensors · 2021Article
- Enhanced Access to the Health-Related Skin Metabolome by Fast, Reproducible and Non-Invasive WET PREP Sampling.Metabolites · 2021Article
- Associations between Stress and Physical Activity in Korean Adolescents with Atopic Dermatitis Based on the 2018-2019 Korea Youth Risk Behavior Web-Based Survey.International journal of environmental research and public health · 2020Article
- Metformin ameliorates animal models of dermatitis.Inflammopharmacology · 2020Article
- Physiological mechanisms determining eccrine sweat composition.European journal of applied physiology · 2020Review
- 2-deoxy-d-glucose Ameliorates Animal Models of Dermatitis.Biomedicines · 2020Article
- Sodium-Glucose Cotransporter 2 Inhibitors: A Case Study in Translational Research.Diabetes · 2019 · on this mapReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sweat includes active components and metabolites, which are needed to maintain skin homeostasis. Component changes in sweat derived from atopic dermatitis (AD) have been reported. To investigate the influence of sweat components on the pathogenesis of AD, we performed a multifaceted assessment, including nuclear magnetic resonance spectroscopy-based metabolomic analysis, and linked these features to clinical features of AD. Distinctive properties of AD sweat are the quite-variation in protein, anti-microbial peptides and glucose concentrations. pH, sodium, and other salt levels in sweat of AD were comparable to that of healthy subjects. Sweat from AD patients with acute inflammation had a more prominent increase in glucose concentration than sweat from healthy individuals or those with AD with chronic inflammation. Topical glucose application delayed recovery of transepidermal water loss in barrier-disrupted mice. Furthermore, the glucose transporter GLUT2 was highly expressed in the lumen of sweat glands from AD patients. AD patients with chronic inflammation had significantly increased GLUT2 mRNA expression and near normal sweat glucose levels. Despite the small sample size in our study, we speculate that the increased glucose levels might be affected by AD severity and phenotype. We hope that this report will bring novel insight into the impact of sweat components on the clinical manifestation of AD.
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