Evidence map›Paper›PMID 29677193›Full record

ArticlePloS one2018

A colorimetric assay for vanillin detection by determination of the luminescence of o-toluidine condensates.

Jin Zhao, Haixiong Xia, Tingyu Yu, Lu Jin, Xuehua Li, Yinghui Zhang, Liping Shu, Lingwen Zeng, Zhixu He

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jin ZhaoGuizhou Provincial Key Laboratory for Regenerative Medicine, Tissue Engineering and Stem Cell Research Center, Department of Immunology, School of Basic Medicine, Guizhou Medical University, Guiyang, China.ORCID 0000-0003-1442-6873
Haixiong XiaGuizhou Provincial Key Laboratory for Regenerative Medicine, Tissue Engineering and Stem Cell Research Center, Department of Immunology, School of Basic Medicine, Guizhou Medical University, Guiyang, China.
Tingyu YuSecond Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
Lu JinGuizhou Provincial Key Laboratory for Regenerative Medicine, Tissue Engineering and Stem Cell Research Center, Department of Immunology, School of Basic Medicine, Guizhou Medical University, Guiyang, China.
Xuehua LiGuizhou Provincial Key Laboratory for Regenerative Medicine, Tissue Engineering and Stem Cell Research Center, Department of Immunology, School of Basic Medicine, Guizhou Medical University, Guiyang, China.
Yinghui ZhangSchool of Food Science and Engineering, Foshan University, Foshan, Guangdong Province, China.
Liping ShuGuizhou Provincial Key Laboratory for Regenerative Medicine, Tissue Engineering and Stem Cell Research Center, Department of Immunology, School of Basic Medicine, Guizhou Medical University, Guiyang, China.
Lingwen ZengSchool of Food Science and Engineering, Foshan University, Foshan, Guangdong Province, China.
Zhixu HeGuizhou Provincial Key Laboratory for Regenerative Medicine, Tissue Engineering and Stem Cell Research Center, Department of Immunology, School of Basic Medicine, Guizhou Medical University, Guiyang, China.
Guiyang Medical University · CNFoshan University · CNGuangzhou University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vanillin (4-hydroxy-3-methoxybenzaldehyde), a food additive with rich milk flavor, is commonly used in the food, beverage and cosmetic industries. However, excessive consumption of vanillin may cause liver and kidney damage. Therefore, methods for detecting and controlling the level of vanillin in food, especially in infant powder, have important practical significance. In this study, we established a colorimetric assay for vanillin detection. The detection was performed under high-temperature and acidic conditions, which can induce the reaction of the aldehyde group of vanillin with the amino group of o-toluidine. The resulting product had a maximum absorption at 363 nm, which was quantified by a UV spectrophotometer. This assay had a limit of detection (LOD) of 1 pg mL-1 and a linear range between 1 μg mL-1 and 100 μg mL-1. The average recoveries at three spiked levels were in the range from 91.1% to 101.6% with a relative standard deviation (RSD) of 4.62% ~ 7.27%.

Indexed as

BenzaldehydesColorimetryFlavoring AgentsFood AdditivesFood AnalysisLimit of DetectionLuminescenceToluidines2-toluidineBenzaldehydesFlavoring AgentsFood AdditivesToluidinesvanillin

Identifiers

PMID29677193
PMCPMC5909897
OpenAlexW2801938673

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.