Evidence map›Paper›PMID 29677167›Full record

ReviewMolecules (Basel, Switzerland)2018

The Role of Catechins in Cellular Responses to Oxidative Stress.

Jurga Bernatoniene, Dalia Marija Kopustinskiene

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 287 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
287citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06235827 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effects of Green Tea Consumption on Retinal Nerve Fiber Layer ( RNFL) and Intraocular Pressure ( IOP) in Patients With Primary Glaucoma

TypeinterventionalSponsorUniversiti Sains MalaysiaRan2024 to 2025Enrolled100ConditionsPrimary GlaucomaArmsGreen tean group, Control group
NCT07149506 phase3enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Efficacy of Oral or Topical Catechins vs. Placebo as an Adjuvant for the Prevention and Management of Radiation Dermatitis in Oncology Patients: a Randomized Trial

TypeinterventionalSponsorCARLOS FRANCISCO SAAVEDRA GARCIARan2025 to 2027Enrolled162ConditionsRadiation Dermatitis Acute, Radiation Dermatitis, Fibrosis, SkinArmsEpicatechin, Epigallocatechin Gallate (EGCG), Microcrystalline Cellulose NF (placebo), Saline (0.9% NaCl)
3 · Its place in the literature

Who cites it

287 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Quantitative proteomics insights into the response mechanisms of Aeromonas hydrophila to chromium stress.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
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  10. Bioactive Metabolites ofBiomedicines · 2026
    Review
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  15. International journal of molecular sciences · 2026
    Article
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227 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jurga BernatonieneDepartment of Drug Technology and Social Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Eiveniu 4, LT-50161 Kaunas, Lithuania. jurga.bernatoniene@lsmuni.lt.
Dalia Marija KopustinskieneInstitute of Pharmaceutical Technologies, Medical Academy, Lithuanian University of Health Sciences, Eiveniu 4, LT-50161 Kaunas, Lithuania. daliamarija.kopustinskiene@lsmuni.lt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Catechins are polyphenolic compounds—flavanols of the flavonoid family found in a variety of plants. Green tea, wine and cocoa-based products are the main dietary sources of these flavanols. Catechins have potent antioxidant properties, although in some cases they may act in the cell as pro-oxidants. Catechins are reactive oxygen species (ROS) scavengers and metal ion chelators, whereas their indirect antioxidant activities comprise induction of antioxidant enzymes, inhibition of pro-oxidant enzymes, and production of the phase II detoxification enzymes and antioxidant enzymes. Oxidative stress and ROS are implicated in aging and related dysfunctions, such as neurodegenerative disease, cancer, cardiovascular diseases, and diabetes. Due to their antioxidant properties, catechins may be beneficial in preventing and protecting against diseases caused by oxidative stress. This article reviews the biochemical properties of catechins, their antioxidant activity, and the mechanisms of action involved in the prevention of oxidative stress-caused diseases.

Indexed as

AnimalsAntioxidantsCatechinDisease SusceptibilityHumansMitochondriaMolecular StructureOxidation-ReductionOxidative StressReactive Oxygen SpeciesAntioxidantsCatechinReactive Oxygen Speciescancercardiovascular diseasescatechinneurodegenerative disordersROS

Identifiers

PMID29677167
PMCPMC6017297

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.