ArticleTransplantation2018
Measured Glomerular Filtration Rate After Kidney Donation: No Evidence of Accelerated Decay.
Article in Transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Donor medicine: An emerging field in nephrology.World journal of nephrology · 2026Review
- Nonindexed versus Body Surface Area-Indexed Measured GFR Determinations as a Criterion of Living Donor Acceptance.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Risk Factors for One-Year Post-Nephrectomy Decline in Renal Function of Living Kidney Donors: Quantile Regression Analysis Based on Estimated Glomerular Filtration Rate Reduction Percentiles.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Renal function outcomes in living kidney donors in a transplant center in Colombia.SAGE open medicine · 2024Article
- Prediction tool for renal adaptation after living kidney donation using interpretable machine learning.Frontiers in medicine · 2023Article
- Renal function outcomes and kidney biopsy features of living kidney donors with hypertension.Clinical transplantation · 2021Article
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4 authors.
Funding
Abstract
backgroundThe rate of measured glomerular filtration rate (GFR) change in kidney donor years after donation has not been adequately addressed. Whether this change is accelerated in the setting of 1 kidney is also understudied.
methodsTwo hundred fourteen randomly selected donors underwent serial GFR measurements of nonradioactive iohexol. Estimated GFR at each visit was calculated using the Chronic Kidney Disease Epidemiology Collaboration and Modification of Diet in Renal Disease study equations.
resultsGlomerular filtration rate visits were 4.8 ± 1.3 years apart and the second occurring 16.9 ± 9.1 years after donation. Most (97.7%) were white, 60.8% female, and 78.5% were related to their recipient. Most, 84.6%, had a GFR of 60 mL/min per 1.73 m or higher, 14.0% had a GFR between 45 and 60 mL/min per 1.73 m, and 1.4% had a GFR less than 45 mL/min per 1.73 m. Between visits 1 and 2, 56.5% had a GFR decline, 36.0% increase, and in 7.5%, there was no change. Overall, GFR declined at a rate of -0.42 mL/min per 1.73 m per year. Of GFR estimating models, only Chronic Kidney Disease Epidemiology Collaboration-Creatinine equation produced a slope that was steeper than measured GFR.
conclusionsNearly 2 decades postdonation GFR declined at a rate similar to that seen in the general population, and in one third, GFR continues to increase.
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