ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)2019
Small Left Ventricular Size Is an Independent Risk Factor for Ventricular Assist Device Thrombosis.
Article in ASAIO journal (American Society for Artificial Internal Organs : 1992), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Observational
- Left Ventricular Assist Device Implantation and Aneurysmectomy for a Giant Left Ventricular Aneurysm.JACC. Case reports · 2026Article
- The approach to placement of a continuous-flow intracorporeal ventricular assist device in small left ventricle.JHLT open · 2025Article
- In Vitro and In Silico Characterization of the Aggregation of Thrombi on Textured Ventricular Cannula.Annals of biomedical engineering · 2024Article
- Empirical and Computational Evaluation of Hemolysis in a Microfluidic Extracorporeal Membrane Oxygenator Prototype.Micromachines · 2024Article
- Impella 5.5 in left ventricular noncompaction syndrome as bridge to heart transplant.JHLT open · 2024Article
- Special Considerations for Advanced Heart Failure Surgeries: Durable Left Ventricular Devices and Heart Transplantation.Journal of cardiovascular development and disease · 2024Review
- Modeling the Mechanical Microenvironment of Coiled Cerebral Aneurysms.Journal of biomechanical engineering · 2023Article
- Advancements in left ventricular assist devices to prevent pump thrombosis and blood coagulopathy.Journal of anatomy · 2023Review
- A Holistic View of Advanced Heart Failure.Life (Basel, Switzerland) · 2022Review
- Design and execution of a verification, validation, and uncertainty quantification plan for a numerical model of left ventricular flow after LVAD implantation.PLoS computational biology · 2022Article
- A New Mathematical Numerical Model to Evaluate the Risk of Thrombosis in Three Clinical Ventricular Assist Devices.Bioengineering (Basel, Switzerland) · 2022Article
- Effects of the atrium on intraventricular flow patterns during mechanical circulatory support.The International journal of artificial organs · 2022Article
- Left atrial appendage occlusion in ventricular assist device patients to decrease thromboembolic events: A computer simulation study.Frontiers in physiology · 2022Article
- Long-Term renal function after implantation of continuous-flow left ventricular assist devices: A single center study.International journal of cardiology. Heart & vasculature · 2021Article
- Multi-constituent simulation of thrombus formation at LVAD inlet cannula connection: Importance of Virchow's triad.Artificial organs · 2021Article
- Pre-implant left ventricular dimension is not associated with worse outcomes after left ventricular assist device implantation.Journal of thoracic disease · 2021Article
- Conventional and alternative sites for left ventricular assist device inflow and outflow cannula placement.Annals of cardiothoracic surgery · 2021Article
- Ventricular assist devices implantation: surgical assessment and technical strategies.Cardiovascular diagnosis and therapy · 2021Review
- The influence of left ventricular assist device inflow cannula position on thrombosis risk.Artificial organs · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
The prevalence of ventricular assist device (VAD) therapy has continued to increase due to a stagnant donor supply and growing advanced heart failure (HF) population. We hypothesize that left ventricular (LV) size strongly influences biocompatibility and risk of thrombosis. Unsteady computational fluid dynamics (CFD) was used in conjunction with patient-derived computational modeling and virtual surgery with a standard, apically implanted inflow cannula. A dual-focus approach of evaluating thrombogenicity was employed: platelet-based metrics to characterize the platelet environment and flow-based metrics to investigate hemodynamics. Left ventricular end-diastolic dimensions (LVEDds) ranging from 4.5 to 6.5 cm were studied and ranked according to relative thrombogenic potential. Over 150,000 platelets were individually tracked in each LV model over 15 cardiac cycles. As LV size decreased, platelets experienced markedly increased shear stress histories (SHs), whereas platelet residence time (RT) in the LV increased with size. The complex interplay between increased SH and longer RT has profound implications on thrombogenicity, with a significantly higher proportion of platelets in small LVs having long RT times and being subjected to high SH, contributing to thrombus formation. Our data suggest that small LV size, rather than decreased VAD speed, is the primary pathologic mechanism responsible for the increased incidence of thrombosis observed in VAD patients with small LVs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.