ArticleThe Journal of physiology2018
Prolonged prenatal hypoxia selectively disrupts collecting duct patterning and postnatal function in male mouse offspring.
Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 22 citations in OpenAlex.
- Sex differences in the sensitization of prenatally programmed hypertension.Frontiers in physiology · 2025Review
- YTHDF3 modulates the Cbln1 level by recruiting BTG2 and is implicated in the impaired cognition of prenatal hypoxia offspring.iScience · 2024Article
- The reduced number of nephrons with shortening renal tubules in mouse postnatal adverse environment.Pediatric research · 2023Article
- Gene-environment interactions in birth defect etiology: Challenges and opportunities.Current topics in developmental biology · 2023Review
- Maternal iron deficiency perturbs embryonic cardiovascular development in mice.Nature communications · 2021Article
- Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress.Nature communications · 2021Article
- COVID-19 During Development: A Matter of Concern.Frontiers in cell and developmental biology · 2021Article
- Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy.Clinical science (London, England : 1979) · 2020Article
- Deletion of hypoxia-responsive microRNA-210 results in a sex-specific decrease in nephron number.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Prenatal hypoxia increases susceptibility to kidney injury.PloS one · 2020Article
- The Placental Transcriptome in Late Gestational Hypoxia Resulting in Murine Intrauterine Growth Restriction Parallels Increased Risk of Adult Cardiometabolic Disease.Scientific reports · 2019Article
- Developmental programming of renal function: nephron endowment and beyond.The Journal of physiology · 2018Article
- Challenges and controversies in perinatal physiology.The Journal of physiology · 2018Article
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6 authors at 3 institutions in 1 country.
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Abstract
key pointsIn the present study, we investigated whether hypoxia during late pregnancy impairs kidney development in mouse offspring, and also whether this has long-lasting consequences affecting kidney function in adulthood. Hypoxia disrupted growth of the kidney, particularly the collecting duct network, in juvenile male offspring. By mid-late adulthood, these mice developed early signs of kidney disease, notably a compromised response to water deprivation. Female offspring showed no obvious signs of impaired kidney development and did not develop kidney disease, suggesting an underlying protection mechanism from the hypoxia insult. These results help us better understand the long-lasting impact of gestational hypoxia on kidney development and the increased risk of chronic kidney disease. ABSTRACT: Prenatal hypoxia is a common perturbation to arise during pregnancy, and can lead to adverse health outcomes in later life. The long-lasting impact of prenatal hypoxia on postnatal kidney development and maturation of the renal tubules, particularly the collecting duct system, is relatively unknown. In the present study, we used a model of moderate chronic maternal hypoxia throughout late gestation (12% O
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