Evidence map›Paper›PMID 29676785›Full record

ArticleEuropean journal of immunology2018

Sustained cross-presentation capacity of murine splenic dendritic cell subsets in vivo.

Nataschja I Ho, Marcel G M Camps, Edwin F E de Haas, Ferry Ossendorp

Open access · hybridAbstract read
In one paragraph

Article in European journal of immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  5. Immunoregulatory function ofOpen life sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nataschja I HoDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-4071-9370
Marcel G M CampsDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.
Edwin F E de HaasDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.
Ferry OssendorpDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An exclusive feature of dendritic cells (DCs) is their ability to cross-present exogenous antigens in MHC class I molecules. We analyzed the fate of protein antigen in antigen presenting cell (APC) subsets after uptake of naturally formed antigen-antibody complexes in vivo. We observed that murine splenic DC subsets were able to present antigen in vivo for at least a week. After ex vivo isolation of four APC subsets, the presence of antigen in the storage compartments was visualized by confocal microscopy. Although all APC subsets stored antigen for many days, their ability and kinetics in antigen presentation was remarkably different. CD8α

Indexed as

Cross-PrimingAnimalsAntigen PresentationCD8 AntigensCD8-Positive T-LymphocytesCells, CulturedDendritic CellsHistocompatibility Antigens Class IHistocompatibility Antigens Class IILymphocyte ActivationMacrophagesMiceMice, Inbred C57BLMicroscopy, ConfocalSpleenCD8 antigen, alpha chainCD8 AntigensHistocompatibility Antigens Class IHistocompatibility Antigens Class IIAntigen presentation/processingCD4 T cellsCD8 T cellsCross presentation/primingDendritic cells

Identifiers

PMID29676785
PMCPMC6055716
OpenAlexW2801179043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.