ArticleeLife2018
Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 90 citations in OpenAlex.
- Medial prefrontal cortex neurons integrate amygdala and hypothalamic oxytocin signals to mediate stress-induced social alterations.Communications biology · 2026Article
- A narrative review on oxytocin at the intersection of sleep, stress, and social behavior.Frontiers in neuroscience · 2026Review
- What electrodes can be used to measure mu rhythm (de)synchronization in the context of speech comprehension studies? An insight from theoretical analysis.Frontiers in human neuroscience · 2026Article
- Vasopressin-to-oxytocin receptor crosstalk in the preoptic area underlying parental behaviors in male mice.Nature communications · 2025Article
- Tactile stimulation reverses painful stimuli outcomes via PVN-VTA oxytocin circuitry and dopaminergic regulation.Communications biology · 2025Article
- Complexity of the Hypothalamic Oxytocin System and its Involvement in Brain Functions and Diseases.Neuroscience bulletin · 2025Review
- An oxytocin receptor gene polymorphism is associated with distinct neural responses to mating encounters in male prairie voles.Hormones and behavior · 2025Article
- Oxytocin signaling in the ventral tegmental area mediates social isolation-induced craving for social interaction.Journal of biomedical science · 2025Article
- The Relationship Between Oxytocin and Alcohol Dependence.Current topics in behavioral neurosciences · 2025Review
- Pedunculoside targets P2X7R to protect against myocarditis by regulating the NLRP3/PIP2/MAPK signaling pathway.Frontiers in pharmacology · 2025Article
- Projections from subfornical organ to bed nucleus of the stria terminalis modulate inflammation-induced anxiety-like behaviors in mice.Science advances · 2024Article
- Oxytocin Protects Against Corticosterone-Induced DA Dysfunction: An Involvement of the PKA/CREB Pathway.Neurochemical research · 2024Article
- Oxytocin Protects Nigrostriatal Dopamine Signal via Activating GABAergic Circuit in the MPTP-Induced Parkinson's Disease Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- MDMA modulates human sensorimotor cortical pathways during gentle touch.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Traditional Japanese medicine Kamikihito ameliorates sucrose preference, chronic inflammation and obesity induced by a high fat diet in middle-aged mice.Frontiers in endocrinology · 2024Article
- Detection, processing and reinforcement of social cues: regulation by the oxytocin system.Nature reviews. Neuroscience · 2023Review
- Peptidergic and functional delineation of the Edinger-Westphal nucleus.Cell reports · 2023Article
- Oxytocin excites dorsal raphe serotonin neurons and bidirectionally gates their glutamate synapses.iScience · 2023Article
- D1 receptor-expressing neurons in ventral tegmental area alleviate mouse anxiety-like behaviors via glutamatergic projection to lateral septum.Molecular psychiatry · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The experience of rewarding or aversive stimuli is encoded by distinct afferents to dopamine (DA) neurons of the ventral tegmental area (VTA). Several neuromodulatory systems including oxytocin regulate DA neuron excitability and synaptic transmission that process socially meaningful stimuli. We and others have recently characterized oxytocinergic modulation of activity in mouse VTA DA neurons, but the mechanisms underlying oxytocinergic modulation of synaptic transmission in DA neurons remain poorly understood. Here, we find that oxytocin application or optogenetic release decrease excitatory synaptic transmission, via long lasting, presynaptic, endocannabinoid-dependent mechanisms. Oxytocin modulation of excitatory transmission alters the magnitude of short and long-term depression. We find that only some glutamatergic projections to DA neurons express CB1 receptors. Optogenetic stimulation of three major VTA inputs demonstrates that oxytocin modulation is limited to projections that show evidence of CB1R transcripts. Thus, oxytocin gates information flow into reward circuits in a temporally selective and pathway-specific manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.