ReviewAnnals of the American Thoracic Society2018
Understanding Root Causes of Asthma. Perinatal Environmental Exposures and Epigenetic Regulation.
Review in Annals of the American Thoracic Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Campesterol attenuates airway inflammation in allergic asthma: insights from a murine model and molecular docking analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Maternal exposure to smoking and wheezing phenotypes in children: a cohort study of the Japan Environment and Children's Study.BMC pediatrics · 2024Article
- Automated Interpretation of Lung Sounds by Deep Learning in Children With Asthma: Scoping Review and Strengths, Weaknesses, Opportunities, and Threats Analysis.Journal of medical Internet research · 2024Article
- Associations of prenatal exposure to phthalates and their mixture with lung function in Mexican children.Journal of hazardous materials · 2024Article
- Association of GAB1 gene with asthma susceptibility and the efficacy of inhaled corticosteroids in children.BMC pulmonary medicine · 2023Article
- Genes, environment, and developmental timing: New insights from translational approaches to understand early origins of respiratory diseases.Pediatric pulmonology · 2021Article
- Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach.The European respiratory journal · 2021Article
- A review of epigenetic changes in asthma: methylation and acetylation.Clinical epigenetics · 2021Review
- Aberrant Methylation of Aging-Related Genes in Asthma.Frontiers in molecular biosciences · 2021Article
- The socioeconomic burden of chronic lung disease in low-resource settings across the globe - an observational FRESH AIR study.Respiratory research · 2019Observational
- Chronic, Elevated Maternal Corticosterone During Pregnancy in the Mouse Increases Allergic Airway Inflammation in Offspring.Frontiers in immunology · 2019Article
- Commentary: Tobacco smoking and asthma: multigenerational effects, epigenetics and multilevel causal mediation analysis.International journal of epidemiology · 2018Article
- Impact of Air Pollution on Asthma: A Scoping Review.Open respiratory archivesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A common explanation for the origins and rising prevalence of asthma is that they involve complex interactions between hereditary predispositions and environmental exposures that are incompletely understood. Yet, emerging evidence substantiates the paradigm that environmental exposures prenatally and during very early childhood induce epigenetic alterations that affect the expression of asthma genes and, thereby, asthma itself. Here, we review much of the key evidence supporting this paradigm. First, we describe evidence that the prenatal and early postnatal periods are key time windows of susceptibility to environmental exposures that may trigger asthma. Second, we explain how environmental epigenetic regulation may explain the immunopathology underlying asthma. Third, we outline specific evidence that environmental exposures induce epigenetic regulation, both from animal models and robust human epidemiological research. Finally, we review some emerging topics, including the importance of coexposures, population divergence, and how epigenetic regulation may change over time. Despite all the inherent complexity, great progress has been made toward understanding what we still consider reversible asthma risk factors. These, in time, may impact patient care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.