Trial reportObesity (Silver Spring, Md.)2018
Short- and Long-Term Changes in Health-Related Quality of Life with Weight Loss: Results from a Randomized Controlled Trial.
Trial report in Obesity (Silver Spring, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05684367 (Center-Based and Home-Based Walking Exercise Intervention to Reduce Fatigue in Older Breast Cancer Survivors), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Center-Based and Home-Based Walking Exercise Intervention to Reduce Fatigue in Older Breast Cancer Survivors
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Depression and obesity among females, are sex specificities considered?Archives of women's mental health · 2021Pooled it
- Semaglutide versus placebo in individuals with poor weight loss after bariatric surgery: a double-blinded, randomized, placebo-controlled trial.Nature medicine · 2026Trial
- Quality of life improvements associated with weight loss using a novel shape-shifting hydrogel capsule: RESET study results.International journal of obesity (2005) · 2026Trial
- Trial
- Clinical efficacy of weight loss herbal intervention therapy and lifestyle modifications on obesity and its association with distinct gut microbiome: A randomized double-blind phase 2 study.Frontiers in endocrinology · 2023Trial
- Health-Related Quality of Life in Weight Loss Interventions: Results from the OPTIWIN Trial.International journal of environmental research and public health · 2021Trial
- Validation of a new measure of quality of life in obesity trials: Impact of Weight on Quality of Life-Lite Clinical Trials Version.Clinical obesity · 2019 · on this mapTrial
- Weight loss is associated with improved quality of life among rural women completers of a web-based lifestyle intervention.PloS one · 2019Trial
- Trial
- The Effects of Different Intervention Protocols on Anthropometric Measures, Lipid Profile, and Quality of Life: Insights from a Pandemic-Era Randomized Controlled Trial.Iranian journal of public health · 2025Article
- The Impact of Digital Technology-Based Exercise Combined With Dietary Intervention on Body Composition in College Students With Obesity: Prospective Study.Journal of medical Internet research · 2025Article
- Tirzepatide Was Associated with Improved Health-Related Quality of Life in Adults with Obesity or Overweight and Type 2 Diabetes: Results from the Phase 3 SURMOUNT-2 Trial.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- Obesity medications: A narrative review of current and emerging agents.Osteoarthritis and cartilage open · 2024Article
- The Role of Lifestyle Modification with Second-Generation Anti-obesity Medications: Comparisons, Questions, and Clinical Opportunities.Current obesity reports · 2023Review
- Semaglutide for the treatment of obesity.Trends in cardiovascular medicine · 2023 · on this mapReview
- Association between weight loss, change in physical activity, and change in quality of life following a corporately sponsored, online weight loss program.BMC public health · 2022Article
- Confirmatory psychometric evaluations of the Impact of Weight on Quality of Life-Lite Clinical Trials Version (IWQOL-Lite-CT).Clinical obesity · 2021Article
- The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism.Frontiers in pharmacology · 2021Review
- Article
- Quality of Life in Yoga Experienced and Yoga Naïve Asian Indian Adults with Obesity.Journal of obesity · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
objectiveThe objective of this study was to determine the effects of weight loss and weight loss maintenance (WLM) on weight-specific health-related quality of life in a 66-week trial.
methodsAdults with obesity (N = 137, 86.1% female, 68.6% black, mean age = 46.1 years) who had lost ≥ 5% of initial weight in a 14-week intensive lifestyle intervention/low-calorie diet (LCD) program were randomly assigned to lorcaserin or placebo for an additional 52-week WLM program. The Impact of Weight on Quality of Life-Lite (IWQOL-Lite) scale (including five subscales), Patient Health Questionnaire-9 (depression), and Perceived Stress Scale were administered at the start of the 14-week LCD program, randomization, and week 52 of the randomized controlled trial (i.e., 66 weeks total).
resultsSignificant improvements in all outcomes, except weight-related public distress, were found following the 14-week LCD program (P values < 0.05). Improvements were largely maintained during the 52-week randomized controlled trial, despite weight regain of 2.0 to 2.5 kg across treatment groups. Participants who lost ≥ 10% of initial weight achieved greater improvements in physical function, self-esteem, sexual life, and the IWQOL-Lite total score than those who lost < 5% and did not differ from those who lost 5% to 9.9%.
conclusionsImprovements in weight-specific health-related quality of life were achieved with moderate weight loss and were sustained during WLM.
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Registered trials
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